Sarcoma Flashcards
What are the two most active chemotherapeutic agents?
A. Doxorubicin and ifosfamide
B. Doxorubicin and daunorubicin
C. Vincristine and etoposide
D. Vinblastine and Ifosfamide
A. Doxorubicin and ifosfamide
Which of the following combinations are effective in both rhabdomyosarcoma and Ewing sarcoma?
A. Vincristine + Vinblastine + Dacarbazine
B. Vincristine + Etoposide + Irinotecan
C. Gemcitabine + Doxorubicin + Rituximab
D. None of the options
B. Vincristine + Etoposide + Irinotecan
Which of the following is the most frequent symptom of tumors metastatic to the bone?
A. Swelling
B. Pain
C. Erythema
D. Fatigue
E. Mass
B. Pain
All of the following are malignant tumors EXCEPT:
A. Chondroblastoma
B. Chondrosarcoma
C. Osteosarcoma
D. Ewing’s sarcoma
E. Any of the options
A. Chondroblastoma - benign
Osteosarcoma has a predilection for metaphysis of long bones. Which of the following is/are common sites of involvement?
A. Proximal femur
B. Distal femur
C. Proximal tibia
D. Distal humerus
E. Two of the options
E. Any of the options
Distal femur, Proximal tibia, Proximal humerus
Which of the following most likely reveals a destructive lesion with a moth-eaten appearance?
A. Xray
B. CT scan
C. Chest CT scan
D. MRI
E. All of the options
A. Xray / Plain radiograph
Which of the following is best for defining bone destruction and the pattern of calcification?
A. Xray
B. CT scan
C. Chest CT scan
D. MRI
E. All of the options
B. CT scan
Which of the following should be used to detect the metastases to the bony skeleton?
A. CT scan
B. MRI
C. Bone scan
D. FDG-PET
E. Two of the options
E. Two of the options
Bone scan and FDG - PET
Which of the following is the standard management for osteosarcoma?
A. Use of chemotherapy drugs
B. Chemotherapy -> Limb-sparing surgery -> Chemotherapy
C. Chemotherapy -> Resection -> Irradiation
D. Chemotherapy -> Irradiation -> Limb surgery
E. Any of the options
B. Chemotherapy -> Limb-sparing surgery -> Chemotherapy
Chondrosarcoma has a predilection for flat bones. Which of the following is/are common sites of involvement?
A. Shoulder
B. Hip bone
C. Proximal tibia
D. Any of the options
D. Any of the options
Shoulder and pelvic girdles, but can also affect the diaphyseal portions of long bones
Mainstay therapy for chondrosarcoma
A. Chemotherapy -> surgery
B. Chemotherapy -> surgery -> irradiation
C. Surgical resection -> chemotherapy
D. Surgical resection only
D. Surgical resection of primary or recurrent tumors is the mainstay of therapy for chondrosarcoma
Mainstay therapy for Ewing’s sarcoma
A. Chemotherapy only
B. Chemotherapy -> surgery
C. Chemotherapy -> surgery -> irradiation
D. Surgical resection -> chemotherapy
A. Systemic chemotherapy is the mainstay of therapy
After several cycles of chemotherapy, the patient was found to have high pulse rate. A noninvasive radionuclide scan revealed evidence of cardiomyopathy. The drug that is most likely responsible for the cardiac toxicity is:
A. Cyclophosphamide
B. Doxorubicin
C. Fluorouracil
D. Methotrexate
E. Idarubicin
B. Doxorubicin
Which of the following is a cell cycle-specific anticancer drug that acts mainly in the M phase of the cell cycle?
A. Bleomycin
B. Cisplatin
C. Etoposide
D. Methotrexate
E. Paclitaxel
E. Paclitaxel
The taxanes, paclitaxel and docetaxel, interfere with the separation of chromosomes during mitosis because of their effects on MTs.
Which of the following drug that is used in combination therapy for testicular carcinoma and also associated with nephrotoxicity?
A. Bleomycin
B. Cisplatin
C. Etoposide
D. Leuprolide
E. Vinblastine
B. Cisplatin = nephrotoxicity
Which of the following is cell cycle specific that binds to the beta-tubulin and prevents formation of microtubules?
A. Vinblastine
B. Etoposide
C. Cisplatin
D. Bleomycin
E. Linezolid
A. Vinblastine
Ewing’s sarcoma is histologically graded as which of the following?
A. GX
B. G1
B. G2
C. G3
D. G4
D. G4
Which of the following drug is most active in the late S and early G2 phases of the cell cycle?
A. Cytarabine
B. Topotecan
C. Vinblastine
D. Methotrexate
E. Etoposide
E. Etoposide (topoisomerase II inhibitor)
All of the following are TRUE about osteosarcoma EXCEPT:
A. Has a predilection for metaphyses of long bones
B. Males are affected 1.5-2 times as often as females
C. 75% of osteosarcomas fall into classic category
D. Patients typically present with pain and swelling
E. None of the options
E. None of the options
Response to which of the following is/are considered the most important prognostic factor for long-term survival of osteosarcoma patients?
A. Chemotherapy
B. Radiotherapy
C. Surgical resection
D. All of the options
A. Chemotherapy
Which of the following presents lesions that may have a lobular appearance with mottled or punctate calcification of the cartilaginous matrix?
A. Enchondroma
B. Chondrosarcoma
C. Ewing’s sarcoma
D. Osteosarcoma
E. None of the options
B. Chondrosarcoma
Which of the following is the mainstay of therapy of chondrosarcoma?
A. Chemotherapy
B. Radiotherapy
C. Surgical resection
D. All of the options
C. Surgical resection
All of the following are TRUE about Ewing’s sarcoma EXCEPT
A. Soft tissue mass is composed of sheets of monotonous, small, round, blue cells
B. Glucagon-filled cytoplasm is seen
C. Plain radiography shows onion peel periosteal reaction
D. Common sites of metastases are lung, bones, and bone marrow
E. None of the options
B. Glucagon-filled cytoplasm is seen
Codman triangle is indicated in which of the following?
A. Osteosarcoma, indolent tumor
B. Osteosarcoma, aggressive tumor
C. Ewing’s sarcoma, indolent tumor
D. Ewing, aggressive tumor
B. Osteosarcoma, aggressive tumor
Mutations in which of the following is present in most osteosarcoma cases?
A. RB
B. TP43
C. CDKN2A
D. MDM2 and CDK4
A. RB
All of the following are TRUE about Ewing’s sarcoma EXCEPT:
A. Arises in the diaphysis of long bones
B. Affected site is rarely tender, warm, and swollen
C. Radiographs show permeative and moth-eaten margins
D. Considered as an aggressive sarcoma
E. None of the options
B. Affected site is rarely tender, warm, and swollen
All of the following are cell-cycle specific EXCEPT:
A. Cisplatin
B. Ifosfamide
C. Methotrexate
D. Doxorubicin
E. None of the options
A. Cisplatin
Which of the following shows popcorn calcification on radiography?
A. Osteosarcoma
B. Chondrosarcoma
C. Rheumatoid Arthritis
D. Ewing’s sarcoma
E. Rhabdomyosarcoma
B. Chondrosarcoma
Which of the following extends from medulla to lift periosteum, and malignant cells produce woven bone?
A. Chondrosarcoma
B. Osteosarcoma
C. Ewing sarcoma
D. Chondroblastoma
E. Chordoma
B. Osteosarcoma
What is the age distribution of osteosarcoma?
A. Unimodal
B. Bimodal
C. Trimodal
D. Multimodal
B. Bimodal
Which of the following staging for bone sarcomas indicate lung metastasis?
A. M1
B. M1a
C. M1b
D. M2
B. M1a
