Systemic lupus erythematosus

Question 1

Define SLE

Answer 1

Multisystemic autoimmune inflammatory disease in
which autoAbs to a variety of autoantigens result in the
formation and deposition of immune complexes.

Question 2

List four features of SLE

Answer 2

Arthritis
Malar rash
Lupus nephritis
Autoimmune haemolytic anaemia 
Immune phenomena
Seizures, psychosis
Discoid rash

Question 3

Name three antibodies that are positive in SLE

Answer 3

ANA
dsDNA
Sm
ENA
anti-phospholipid
lupus anticoagulant

Question 4

Name two drugs that can induce SLE

Answer 4

phenytoin
isoniazid
hydralazine

Question 5

Which syndrome can develop secondary to SLE?

Answer 5

anti-phospholipid syndrome

Question 6

Antiphospholipid syndrome makes you prone to?

Answer 6

clotting- venous and arterial due to coagulation defect

Question 7

Which clotting test is abnormal in antiphospholipid syndrome?

Answer 7

APTT

Question 8

Two treatments for SLE?

Answer 8

Treat kidney symptoms- ACEi

Acute flare- steroids

Cutaneous symptoms- topical steroids

Question 9

Two risk factors for SLE?

Answer 9

female, reproductive age, ethnicity

Question 10

When is SLE commonly diagnosed?

Answer 10

40-50

Question 11

How can the presentation of SLE be categorised?

Answer 11

1. constitutional symptoms (fever, weight loss)
2. Cutaneous manifestations
3. Arthralgia and arthritis

Question 12

Name two skin manifestations of SLE

Answer 12

discoid lupus, and cutaneous lupus erythematous

Question 13

Name two organ systems affected in SLE

Answer 13

Renal
CDV
Neuro
Haematological

Question 14

Which antibody strongly correlates to SLE?

Answer 14

ANA- antinuclear antibody

Question 15

How can you assess progress of disease activity in SLE?

Answer 15

complement levels (reduction in level correlates to flare) and dsDNA