Systemic JIA Flashcards
what is the most common chronic rheumatic disease of childhood?
- JIA
criteria for dx of JIA
- < 16 years old
- arthritis in 1 or more joints for > 6 weeks
is there a specific laboratory test for dx of JIA
some lab findings
- no
- increased WBCs
- normocytic, hypochromic anemia
- increased ESR and CRP
oligoarthritis is how many joints
onset age
affects males/females
which extremities
prognosis for outgrowing
< 4 joints
- between 1-2 years old
- females
- affects lower extremities (knee or ankle)
- good prognosis for outgrowing
patients with JIA may present with which eye pathology
unlateral or bilateral
which subtype of JIA is most likely to get it
- uveitis
- bilateral
- oligoarthritis
frequency of eye exams determined by duration of disease and ______ antibody status
- ANA
- eye exams every 3 months
polyarthritis affects how many joints
RF pos/neg - which one most common
how likely are children to outgrow it?
> 5
- RF neg most common
- less likely
RF negative polyarthritis has a peak onset of what age
what sex more affected
affects what parts of body
- 1-3
- through adolescence
- female
- knees, wrist, ankles
RF positive polyarthritis has a what other antibody present
- anti-CCP
RF positive polyarthritis peak onset
what sex most involved
what is the remission late
- 9-11
- females
very low
RF positive polyarthritis involves what joints
symmetric/asymmetric
- large/small joints
- upper/lower extremities
- symmetric
rheumatoid factor antibodies bind the ___ portion of Ig_
most common antibody that is RH factor
- Fc portion of IgG
- IgM
what is a predictor of disease course in JIA
more/less aggressive disease
- rheumatoid factor
- more aggressive disease
anti-CCP Ab is specific for which condition and may be a predictor for its disease course
- rheumatoid arthritis
enthesitis related arthritis is associated with which HLA
- B-27
enthesitis related arthritis has what age of onset
affects which sex
symmetric/asymmetric joint involvement
- late childhood/adolescence
- males more
- asymmetric
which form of arthritis presents with sacroillitis with or without spondylitis
- enthesitis related arthritis
juvenile psoriatic arthritis has what additional conditions besides arthritis and psoriasis
- dactylitis (sausage digit)
- nail pitting/onycholysis (psoriasis of nails)
- psoriasis in a first degree relative
cause of systemic JIA
- phagocytic dysregulation
- overproduction of pro-inflammatory cytokines
- aberrant activation of phagocytes
criteria of dx for systemic JIA
- fever > 2 weeks duration with at least 3 days quotidian
- arthritis in any joint for at least 6 weeks
ANY OF THE FOLLOWING - salmon-pink macular rash, migratory
- generalized lymphadenopathy
- splenomegaly/hepatomegaly
- serositis
- leukocytosis
- anemia
are autoantibodies common for systemic JIA
- no
major cause of death in secondary amyloid as a result of JIA
- renal failure
MOA of Anakinra
used to treat
- IL-1 inhibitor
- competes with IL for binding to receptor
- JIA
MOA of Canakinumab
used to treat
- IL-1 inhibitor
- directly targets IL-1
- JIA
majority of inflammatory diseases are due to IL-___ activity
- IL-1
side effects of IL-1 inhibitors
- increased risk of infections
- cytopenias
do you give live viral vaccines with IL-1 inhibitors
- no
signaling only initiated when IL-6-IL-6-R complex associates with ____
signaling then initiated via ______ pathway
- gp130
- JAK-STAT
adverse affects of Tocilizumab
this drug is used for what conditions
- increased risk of infections
- changes in blood cell counts
- liver toxicity
- RA/JIA
which sex gets systemic JIA more
- equal among sexes
