Dermatomyositis Flashcards
what idiopathic inflammatory myopathy is represented by:
- proximal muscle weakness
- no rash
- polymyositis
what idiopathic inflammatory myopathy is represented by:
- slow onset of weakness over years
- men>women
- distal weakness along with proximal weakness
- inclusion body myositis
what is the most common myopathy after 50 years of age
- inclusion body myositis
is inclusion body myositis associated with a malignancy
- no
what idiopathic inflammatory myopathy is represented by:
- acute onset of proximal muscle weakness and myalgia
- HMGCR antibodies
- necrotizing autoimmune myopathy
which muscles are weak in dermatomyositis
- proximal muscles
- shoulder/hip girdle/neck flexors
cutaneous findings in dermatomyositis
- heliotrope rash
- shawl sign
- Gottrons papules
calcinosis in dermatomyositis occurs more commonly in what population
- children
what syndrome is characterized by: (can present with dermatomyositis or polymyositis)
- inflammatory myopathy
- Raynaud phenomenon
- ILD
- mechanic’s hands
important antibodies to recognize
- anti-synthetase syndrome
- Anti-Jo-1
- Anti-SRP
lab features of dermatomyositis
- elevated CK/aldolase
- elevated CRP
what is a major cause of morbidity and mortality in dermatomyositis
- interstitial lung disease
what myositis is classified by:
- prominent skin disease
- very little muscle involvement
- rapidly progressive lung disease
what antibodies do you look for
- amyopathic dermatomyositis
- anti-MDA-5 (anti-CADM-140)
what is essential to confirm diagnosis of an inflammatory myopathy
- muscle biopsy
where is the localization in dermatomyositis
what T cells are involved
- perimysial
- CD4
where is the localization in polymyositis
what T cells are involved
- endomysial
- CD8
where is the localization in necrotizing autoimmune myositis
what T cells are involved
- just muscle fiber necrosis
- rarely any involved
which antibody in dermatomyositis has the highest risk of cancer
- Anti-Tif-gamma
what cancers do women get with dermatomyositis
- breast
- ovarian
what cancers do men get with dermatomyositis
- prostate
- lung
what antibody in dermatomyositis will present with more rash than myositis
- will also present with severe muscle weakness
- anti-Mi-2
treatment of dermatomyosiits
- corticosteroids
- followed by MTX/AZA
- IVIg early
- exercise and rehab
most patients with dermato/polymyositis will have what kind of disease course
- chronic remitting course
dermatomyositis is associated with malignancy in ___ percent of cases
- 1/4th
