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MOS > SLE > Flashcards

SLE Flashcards

1
Q

which population of people usually gets lupus?

A
  • women in reproductive years
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2
Q

low physiologic level of self-reactivity plays an essential role in what

A
  • lymphocyte selection and maintenance of normal immune system
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3
Q

problem with B cells in SLE

A
  • defective selection/signaling

- autoantibody production

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4
Q

problem with T cells in SLE

A
  • increased numbers of Th17 and Th2
  • decreased Tregs
  • less susceptible to activation-induced death
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5
Q

problem with PDCs in SLE

A
  • produce large amount of interferon

- stimulation activation and proliferation of auto reactive T and B cells

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6
Q

natural autoantibodies are Ig__

pathogenic autoantibodies are Ig_

A
  • IgM

- IgG

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7
Q

pathogenic autoantibodies directly target cells through cross-reactivity with

A
  • other antigens
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8
Q

ANA in SLE is sensitive or specific

A
  • sensitive
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9
Q

what is the most reliable method for detection of ANA

A
  • immunofluorescence
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10
Q

because of low specificity, ANA usefulness increases with the pretest probability for lupus is (high/low)

A
  • high
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11
Q

anti-ds DNA is specific in lupus for ____-

A
  • nephritis
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12
Q

Anti-Smith is specific in lupus for _____

A
  • no specific organ

- against snRNPs

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13
Q

why is the crithidia assay felt to be more specific because of the kinetoplast

A
  • because kinetoplast contains only dsDNA
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14
Q

SLE is characterized by periods of ____ and periods of ____

A
  • periods of flare

- periods of remission

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15
Q

predictors of SLE flare include:

  • new evidence of ______ consumption
  • rising _____ titers
  • increased ____ (marker)
  • new _____ (hematologicL
A
  • complement
  • anti-dsDNA
  • increased ESR
  • new lymphopenia
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16
Q

if you have a young woman presenting with a stroke, what condition should you think of?

A
  • lupus!
17
Q

mucocutaneous system in SLE symptoms

A
  • malar rash
  • discoid rash
  • oral ulcers
  • photosensitivity
18
Q

musculoskeletal symptoms in SLE

A
  • arthralgia
  • jaccoud’s arthropathy (deforming inflammatory arthritis)
  • inflammatory myopathy (inc CPK/aldolase)
  • fibromyalgia
  • avascular necrosis
19
Q

avascular necrosis has an increased risk with what medications

A
  • high dose steroids
20
Q

neuropsychiatric symptoms of SLE

A
  • altered mental status
  • CVA
  • depression
  • seizure
  • mononeuritis multiplex
  • neuropathy
  • Gillian barre, myasthenia gravis
21
Q

the major risk for a CVA in SLE is in the first ___ years of disease

90% of CVAs are what type
10% are what type

A
  • 5
  • ischemic
  • hemorrhagic
22
Q

GI symptoms of lupus

A
  • nonspecific symptoms of n/v/anorexia
  • dysphagia or pain with swallowing
  • GERD
  • mesenteric vasculitis
  • lupus enteritis
23
Q

hematologic symptoms of lupus

A
  • anemia (ACD, iron deficiency, AIHA)
  • leukopenia (lymphopenia)
  • thrombocytopenia (ITP)
24
Q

what is an acquired disorder associated with circulating autoantibodies to anionic phospholipids and their protein binding complexes

A
  • antiphospholipid antibody syndrome
25
Q

the primary clinical manifestations of antiphospholipid syndrome are

A
  • thromboses
26
Q

secondary antiphospholipid syndrome is often associated with which disease

A
  • SLE
27
Q

autoantibodies to test for antiphospholipid syndrome

A
  • anticardiolipin
  • anti-beta 2-glycoprotein
  • lupus anticoagulant
28
Q

treatment for antiphospholipid syndrome

A
  • anticoagulation
29
Q

pulmonary disease of SLE

A
  • restrictive pulmonary disease
  • lupus pleuritis
  • pleural effusion
  • pulmonary hemorrhage
30
Q

lupus pneumonitis occurs during a ____

A
  • flare
31
Q

lupus pneumonitis looks like ____-

A
  • infectious pneumonia
32
Q

a patient who has an abrupt onset of dyspnea, cough, fever, infiltrates, and a dramatic fall in hemoglobin most likely has what

A
  • pulmonary hemorrhage
33
Q

heart diseases in SLE

A
  • pericarditis
  • myocarditis
  • Libman sacks endocarditis
34
Q

which antimalarial do we use in treating SLE

MOA

A
  • hydroxychloroquine
  • antagonist on TLR 3,7,8,9
  • decreases innate activation of innate immune system
  • also has anticoagulant properties
35
Q

what is the first FDA approved treatment for SLE

A
  • Belimumab

MOS (8 decks)

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