Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MOS > Pharm > Flashcards

Pharm Flashcards

1
Q

what is the mainstay of therapy for many chronic inflammatory and autoimmune diseases

A
  • glucocorticoids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

the mechanism of action of glucocorticoids is via regulation of _______

A
  • transcription
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what cellular processes do glucocorticoids suppress

A
  • macrophage activation
  • cellular immunity
  • cytokine production
  • WBC trafficking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

some side effects of glucocorticoids

A
  • CNS effects
  • fluid retention/weight gain/Cushings
  • hyperglycemia
  • HTN
  • infection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

things to do before starting patients on glucocorticoids

A
  • PPD test
  • check vaccination
  • measure bone density to reduce risk for osteoporosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what anti malarial drug is used for autoimmune disease

A
  • hydroxychloroquine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MOA of hydroxychloroquine

A
  • inhibit TLR signaling

- decrease cytokines, lymphocytes, NK activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what conditions do we use hydroxychloroquine in

A
  • SLE
  • RA
  • Sjogren
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

contraindications of hydroxychloroquine

A
  • retinopathy

- G6PD deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

adverse events of hydroxychloroquine

A
  • retinal toxicity

- myopathy/cardiomyopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

screening for hydroxychloroquine

A
  • ophthalmology screening
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA of methotrexate

A
  • inhibits DHFR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what conditions do we use methotrexate with

A
  • rheumatic diseases

- inflammatory diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the drug of choice with rheumatoid arthritis

A
  • methotrexate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what must you give with MTX to avoid oral ulcers and other side effects

A
  • folic acid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

side effects of MTX

A
  • mucosal ulceration
  • hepatotoxicity
  • bone marrow toxicity
  • pneumonitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is important to monitor in patients taking MTX

A
  • liver function tests
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

can you use methotrexate in pregnancy

A
  • no
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

drug interactions with MTX

A
  • sulfamethoxazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

MOA of leflunomide

A
  • inhibits dihydroorate dehyrogenase
  • reduces pyrimidine synthesis
  • reduces activated T cells
21
Q

for what conditions do you use leflunomide

A
  • inflam arthritis

- SLE

22
Q

can you use lefluonimide in pregnancy

A
  • no
23
Q

side effects of lefluonimide

A
  • rash
  • alopecia
  • diarrhea
24
Q

toxicities of lefluonimide

A
  • liver tox

- bone marrow tox

25
Q

what do you give in case of toxicity or pregnancy on lefluonimide

A
  • chlestyramine
26
Q

what conditions do you give Azathioprine to treat

A
  • SLE
  • systemic vasculitis
  • inflammatory myopathy
27
Q

toxicities of azathioprine

A
  • infection
  • bone marrow
  • hepatotoxicity
  • malignancy
28
Q

what do you measure to check bone marrow toxicity in patients on azathioprine

A
  • thiopurine methyltransferase
29
Q

drug interactions with Azathioprine

A
  • allopurinol
  • sulfasalazine
  • trimethoprim
  • ACE-inhibitors
30
Q

can you use azathioprine in pregnancy

A
  • yes!
31
Q

you can use mycophenolate in these conditions

A
  • SLE
  • scleroderma lung disease
  • inflammatory myopathy
  • vasculitis
32
Q

side effects of mycophenolate

A
  • dyspepsia
  • diarrhea
  • rash
33
Q

adverse effects of mycophenolate

A
  • CMV infections
  • bone marrow suppression
  • malignancy
34
Q

MOA of cyclophosphamide

A
  • alkylating agent
35
Q

conditions cyclophosphamide treats

A
  • SLE
  • vasculitis
  • scleroderma
36
Q

what do you give with cyclophosphamide to protect the bladder from dyspepsia

what is the bad breakdown product

A
  • MESNA

- acrolein

37
Q

toxicities of cyclophosphamide

A
  • infection risk
  • hemorrhagic cystitis
  • infertility
  • bone marrow suppression
38
Q

what conditions do we use TNF alpha inhibitors in

A
  • rheumatoid arthritis
  • psoriatic arthritis
  • juvenile arthritis
39
Q

do we use TNF alpha inhibitors in lupus

why?

A
  • no

- worsen disease

40
Q

adverse effects of TNF alpha inhibitors

A
  • reactivation of extrapulmonary TB or Hep B
41
Q

do we give live vaccines with monoclonal antibodies

A
  • NO
42
Q

MOA of rituximab

A
  • against CD20

- depletes B cells

43
Q

what conditions do we use rituximab for?

A
  • rheumatoid arthritis
  • ANCA
  • SLE
44
Q

adverse effects of rituximab

A
  • serum sickness
  • reactivation of Hep B
  • progressive multifocal leukoencephalopathy
45
Q

MOA of Tocilizumab

A
  • blocks IL-6 signaling
46
Q

what conditions do we use tocilizumab to treat?

A
  • RA
  • juvenile arthritis
  • giant cell arthritis
47
Q

MAO of Belinumab

A
  • blocks activation of Blys/BAFF

- Blys/BAGG binds to autoreactive B cells and helps them to produce autoantibodies.

48
Q

what do we use Belinumab to treat

A
  • refractive SLE
49
Q

what do we use IVIg to treat

A
  • Kawasaki dz
  • ITP
  • SLE
  • inflammatory myopathy

MOS (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions