Systemic Diseases with Glomerular involvement Flashcards
What causes these typese of lesions?
what is seen in C?
This is a hallmark for what?
These are lesions of Systemic Lupus Nephritis.
C shows wire loop lesions which are characteristic of Class IV- Diffuse Lupus.
All types of lesions caused by lupus are the result of deposition of immune complexes
What is this?
what conditions are they associated with?
Tubuloreticular inclusions are associated with lupus nephritis and HIV associated nephropathy
what is this?
what characterizes this condition?
Renal Amyloidosis
characterized by extracellular accumulation of B-pleated proteins
what is the most common form of Amyloidosis in the developed world?
what is it?
does it show birefringence with congo red stain?
the most common form of amyloidosis in the developed world is primary amyloidosis.
Amyloid precursor protein is a light chain protein
if treated with potassium permanganate before congo red will not have an affect on the birefringence of primary amyloidosis, so YES.
what type of amyloidosis develops in patients with chronic inflammatory disorders?
what is the precursor protein?
does it show birefringence?
secondary amyloidosis develops in patients with chronic inflammatory disorders of autoimmune etiology (RA, TB, Chron Disease)
the precursor protein for secondary amyloidosis is serum amyloid A (SAA)
if treated with potassium permanganate it will not show birefringence
What is this?
what part of the glomerulus shows abnormality?
what causes the abnormality?
what do we see on IF?
How does the patient present?
this is IgA nephropathy (berger disease)
the mesangium is widened due to increases in the mesangial cells and matrix
the increase in cells is caused by aggregates of underglycosylated IgA that is trapped in the mesangium
Berger disease usually presents in childhood. RBC casts in urine, hematuria and usually follows a mucosal infection
what is a well known complication of nephrotic syndrome?
who is at greatest risk for renal vein thrombosis?
urinary losses of _____ due to increased glomerular permeability can be one cause of this complication
HYPERCOAGULABILITY
Pts with membranous nephropathy and a serum albumin of >2.0 g/dl are at the highest risk for renal vein thrombisis
urinary losses of antithrombin III due to increased glomerular permeability can be one cause of hypercoaguability
a patient presents with isolated hematuria (he may also have vision and hearing disturbances)
what is his condition?
what is the inheritance pattern?
what is mutated/
isolated hematuria is a hallmark for alport syndrome. It shows x-linked inheritance and a mutation of COL IV -alpha5 for type IV collagen
