Systemic Disease Skin Manifestation

Question 1

What is it?

What is it associated with?

Answer 1

1/ Delayed hypersensitivity
Cause unknown
2/ Associated with autoimmune thyroid, diabetes, lymphoma
improves over a few months

(ref; dermnetnz)

Question 2

Dermatitis herpetiformis

Answer 2

Associated with Coeliac Disease
IgA against transglutaminases -> cross reaction between these ab’s and epidermal transglutaminases

Skin biospy req’d for dx

Tx: dapsone in early stages of tx, check no g6pd, otherwise nil gluten
(Ref: RACGP)

Question 3

Pyoderma Gangrenosum
1/ associated with ?
2/ Is this condition an infection?
3/ Tx?

Answer 3

1/ inflammatory bowel disease, rheumatoid arthritis
2/ It’s part of a group of inflammatory disorders (neutrophillic dermatoses)
3/ Steroids and surgery

Question 4

Erythema Nodosum
Causes?
Treatment?

Answer 4

1/Is a reactive inflammation of subcutis or panniculitis to certain antigens 
2/
idiopathic 55% 
Infection 20%
  bacterial (TB), viral (e.g. hsv, hbv, hsv), throat infections
  fungal, parasitic 
Sarcoid 13%
Adverse drug rxn (e.g. ocp) 
Pregnancy 
Inflammatory bowel disease e.g. crohn's 
3/ 
Has a self limiting course, resolves in 6-8 weeks without treatment 

(ref: dermnetnz)