Systemic Corticosteroids Flashcards
Mechanism of action
Decrease inflammation
Increase response to B2 agonists
Methylprednisolone dosage form
tablet
Methylprednisolone age range
all ages
Prednisolone dosage forms
Tablets
Oral liquid
Prednisolone age range
All ages
Prednisone dosage forms
Tablets
Oral liquid
Prednisone age range
All ages
Dexamethasone dosage forms
Oral Liquid
Tablets
Injection
Dexamethasone age range
All ages
Methylprednisolone acetate dosage form
Respiratory injection
Methylprednisolone acetate age range
all ages
AE and Clinical Pearls
AE: short term use-hyperglycemia, increased appetite, fluid retention, demargination of WBCs, psychiatric disturbances
CI: Systemic fungal infections, administration of live vaccines if immunocompromised
DI: Warfarin INR increases, decreased efficacy of inactived vaccines
May be used with ICS if patient is already taking ICS before hospitalization
May also be used for chronic therapy in both asthma (and COPD) only in severe stages
“Bursts” effective for establishing control when initiating therapy or during period of gradual deterioration
Injection may be used in place of “burst” if adherence is an issue or patient is vomiting