Phosphodiesterase-4 inhibitors Flashcards

1
Q

Mechanism of action

A

Inhibits PDE4 leading to increased cAMP

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2
Q

Roflumilast brand name

A

Daliresp

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3
Q

Roflumilast dosage form

A

Tablet

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4
Q

Roflumilast age range

A

12 and up

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5
Q

Roflumilast AE and Clinical Pearls

A

AE: HA, weight loss, diarrhea, nausea
Monitoring: liver function test, weight
DI: CYP3A4 (major), CYP1A2 (minor)
CI: Child-pugh class B or C

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