Leukotriene Modifiers

Question 1

Mechanism of action

Answer 1

Block the production of leukotrienes

Question 2

Montelukast brand name

Answer 2

Singulair

Question 3

Montelukast dosage forms

Answer 3

Tablets, granule packets

Question 4

Montelukast age range

Answer 4

all ages

Question 5

Montelukast AE and Clinical Pearls

Answer 5

Minor substrate of CYP2C8/9 and 3A4

Not for acute relief of symptoms

Question 6

Zafirlukast brand name

Answer 6

Accolate

Question 7

Zafirlukast dosage form

Answer 7

Tablet

Question 8

Zafirlukast age range

Answer 8

5 and up

Question 9

Zafirlukast AE and Clinical Pearls

Answer 9

Take at least 1 hour before or 2 hours after meals
Can increase INR
Major substrate, minor inhibitor of CYP 2C9

Question 10

Zileuton brand name

Answer 10

Zyflo CR

Question 11

Zileuton dosage forms

Answer 11

IR and ER tablets

Question 12

Zileuton age range

Answer 12

12 and up

Question 13

Zileuton AE and Clinical Pearls

Answer 13

Weak CYP1A2 inhibitor

Take with food

Question 14

AE and Clinical Pearls

Answer 14

AE: neuropsychiatric events (agitation, anxiety, abnormal dreams, hallucinations, depression, suicidal thinking), Churg-Strauss syndrome (rare), increased hepatic transaminases (zafirlukast and zileuton)
Less effective than low dose ICS and ICS/LABA in asthma
Have not been adequately trialed in COPD