SYSTEMIC ANATOMY, PHYSIOLOGY AND PATHOLOGY Flashcards
Saggital Plane
Divides vertically
Medial vs. lateral
Flexion/extension around a mediolateral/coronal/frontal axis
Transverse/Horizontal Plane
Divides horizontally
Superior vs inferior
Rotation around a vertical/superioinferior axis
Frontal/Coronal Plane
Divides vertically
Anterior vs posterior
Ab/adduction around an anterioposterior/saggital axis
Cranial Cavity
Formed by cranial bones, contains brain
Vertebral Cavity
Formed by vertebrae; contains spinal cord and beginning of spinal nerves
Thoracic Cavity
Contains pleural cavity, pericardial cavity, and mediastinum
Pleural Cavity
Potential space between pleural layers that surround the lungs
Pericardial Cavity
Potential space between layers of pericardium that surround the heart
Mediastinum
Central portion of thoracic cavity between lungs
First rib –> diaphragm
Sternum –> vertebral column
What is contained within the mediastinum?
Heart, thymus, esophagus, trachea, several large blood vessels
Abdominal Cavity:
Contains stomach, spleen, liver, gallbladder, small intestine and part of the large intestine
Serous membrane of the abdominal cavity:
Peritoneum
Pelvic Cavity:
Contains urinary bladder, portions of the large intestine, internal reproductive organs.
Serous membrane of the pericardial cavity
Pericardium
Serous membrane of the pleural cavity
Pleura
The abdominal quadrants
Right upper, left upper, right lower, left lower
Midsaggital and transverse lines through umbilicus
The abdominal regions
Right hypochondriac, Epigastric, Left hypochondriac
Right lumbar, Umbilical, Left Lumbar
Right inguinal, Hypogastric, Left inguinal
Radiography
Xray
Single barrage of xrays sent through body
Good for imaging dense objects like bone
MRI
Magnetic resonance imaging
Body exposed to high-energy magnetic field.
Resulting proton arrangement read by computer
Good for imaging soft tissue but not bone.
Best for differentiating normal vs abnormal tissue
Computed Tomography (CT/CAT) Scan
Computer assisted xray
Arc of xrays creates image of transverse segment
Positron Emission Tomography (PET) scan
Substance that emits positrons is injected and the resultant gamma rays read
Shows physiology not just anatomy.
Chemical element
Cannot be split into a simpler substance by ordinary means
How many elements are there?
118 (92 on Earth)
Major elements in the body
Oxygen (65% of body mass)
Carbon (18.5%)
Hydroden (9.5%)
Nitrogen (3.2%)
Oxygen: significance in body
Part of water and many organic molecules
Used to generate ATP
Carbon: significance in body
Forms backbone chains/rings of all organic molecules
Hydrogen: significance in body
Constituent of water and most organic molecules
When ionized makes fluids more acidic
Nitrogen: significance in body
Component of all proteins and nucleic acids
Atom:
Smallest unit of matter than retains the properties and characteristics of the element
Atomic number
The number of protons in the nucleus
Mass Number
Sum of protons and neutrons
Isotopes
Atoms of an element that have the same number of protons but different number of neutrons
Same atomic #, different mass #
Half-life
The time it takes for half of the radioactive atoms in an isotope to decay into a more stable form
Half life of C-14: 5730 years
Atomic Mass
Average mass of all the naturally occurring isotopes, measured in daltons
Ion
Positively or negatively charged atom
Molecule
When two or more atoms share electrons
Compound
Joined atoms of two of more different elements
Free Radical
Atom or group of atom with an unpaired electron in its outer shell
Horizontal row in the periodic table
Period
# of electron shells
Designated with Roman Numerals (I, II, III etc)
Vertical row in the periodic table
Group. # of electrons Similar but not identical properties Equally reactive Numbered 1-7
Ionic Bonds
Formed with one atom donates electrons to another
The resulting positive/negative charges pull them together
Example: NaCl
Cation
Positively charged ion.
Electron donor
Anion
Negatively charged ion
Electron recipient
Covalent Bonds
When atoms share electrons
The more electrons shared, the stronger the bond
Single Covalent Bond
One electron shared
Example H2, or H-H
Double Covalent Bond
O2, or O=O
Polar Covalent Bond
Electrons not shared equally
Hydrogen Bond
Polar covalent bond involving Hydrogen Weakly negative (δ-) attracts (δ+) neighbour
Weak – can’t create molecules but can create surface tension of water
Exergonic Reactions
Release more energy than they use
Endergonic Reactions
Use more energy than they release
Catalysts
Decrease the activation energy required, thereby speeding up the reaction.
Unchanged by reaction
ie. Enzymes
Oxidation
Loss of an electron
Reduction
Gain of an electron
Potential Energy
The energy stored by matter due to its position
Chemical Energy
A form of potential energy contained within chemical bonds
Kinetic Energy
Energy associated with matter in motion
Energy
The capacity to do work
Activation Energy
Collision energy required to break chemical bonds of reactants
Anabolic reactions are usually
Endergonic
Catabolic reactions are usually
Exergonic
Inorganic compounds
Usually contain H
Usually don’t contain C
Structurally simple
Include H2O, many salts, acids, bases
Inorganic compounds that contain C include:
CO2
HCO3-
H2CO3
How much of people is inorganic
55-60% H2O plus another 1-2% other inorganic material
Hydrolysis
Addition of water in a catabolic reaction (ie digestion)
Dehydration synthesis reaction
Removal of water in an anabolic reaction (ie protein synthesis)
Water’s polarity is awesome because:
- it makes an excellent solvent for ionic compounds
- it makes it sticky
- allows it to resist temperature changes
Mixture
Blend without bonds
Solution
Solutes small, remain evenly dispersed. Solution transparent
Colloid
Solutes large enough to refract light. Solution opaque or translucent
Suspension
Solutes will eventually separate and settle
Dissociation
When inorganic acids, bases or salts dissolve in water and separate into ions surrounded by water molecules
Acids
Dissociate into one or more H+ ions plus anions
Bases
Dissociate into one or more OH- plus cations
Salts
Dissociate into cations and anions that aren’t H+ or OH-
Electrolytes
Salts which are important for carrying electrical signals, especially in muscles and nerves
What happens when acids and bases react with each other?
They make salts
pH
Measure of acidity/alkalinity
1 (most acidic) to 14 (most basic)
7=neutral
Buffer Systems
A weak acid and the salt of that acid, which acts as a weak base.
Regulate pH homeostasis
Three major buffer systems in the body
Protein Buffer System
Phosphate Buffer System
Carbonic Acid-Bicarbonate buffer system
Protein Buffer System
Most abundant buffer system in ICF and plasma Carboxyl group (-COOH) acts as acid; amino group (NH2) acts as base
Includes hemoglobin buffering of CO2/H+
Phosphate Buffer System
Important regulator in cytosol; also in urine and ECF Dihydrogen phosphate (acid) and monohydrogen phosphate (base)
Carbonic Acid and Bicarbonate buffer system
ICF and ECF
If too acidic bicarbonate (HCO3-) combines with H+ to create carbonic acid (H2CO3)
If too basic carbonic acid dissociates into H+ and HCO3-.
Carbonic acid can also dissociate into H2O and CO2, which is then exhaled.