Synovial Fluid Flashcards

1
Q

viscous liquid found in the cavities of the movable joints

A

Synovial fluid/ joint fluid

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2
Q

The synovial membrane contains specialized cells called

A

Synoviocytes

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3
Q

macrophage-like cells located in the superficial layer of the synovial membrane

A

Type A cells

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4
Q

play an important role in phagocytosis.

A

Type A cells

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5
Q

fibroblast-like cells with prominent endoplasmic reticulum

A

Type B cells

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6
Q

reduce friction between the bones during joint movement

A

smooth articular cartilage and synovial fluid

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7
Q

formed as an ultrafiltrate of plasma across the synovial membrane.

A

Synovial fluid

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8
Q

synoviocytes secrete a mucopolysaccharide containing

A

hyaluronic acid and a small amount of protein

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9
Q

Damage to the articular membranes produces pain and stiffness in the joints, collectively referred to as a

A

arthritis.

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10
Q

Synovial fluid is collected from a joint by needle aspiration

A

Arthrocentesis

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11
Q

Volume Normal Synovial Fluid Values

A

<3.5 mL

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12
Q

Color Normal Synovial Fluid Values

A

Colorless to pale yellow

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13
Q

Clarity Normal Synovial Fluid Values

A

Clear

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14
Q

Viscosity Normal Synovial Fluid Values

A

High; Able to form a string
4-6 cm long

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15
Q

Leukocyte count Normal Synovial Fluid Values

A

<200 cells/uL

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16
Q

Neutrophils count Normal Synovial Fluid Values

A

<25% of the differential

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17
Q

Glucose: plasma difference Normal Synovial Fluid Values

A

<10 mg/dI lower than the blood
glucose level

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18
Q

Total protein Normal Synovial Fluid Values

A

<3 g/dL

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19
Q

Lactate Normal Synovial Fluid Values

A

<25.0 mg/dL

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20
Q

Tube 1

A

Red stopper tube chemical or immunologic analysis.

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21
Q

Tube 3

A

Sodium heparin (green), sodium polyanethol sulfonate (yellow stopper) for microbiological studies.

22
Q

Synovial fluid viscosity comes from

A

polymerization of the hyaluronic acid

23
Q

Hyaluronate polymerization can be measured using a

A

Ropes, or mucin clot test.

24
Q

group 1

A

Non inflammatory

25
Q

Tube 2

A

Sodium heparin, EDTA for hematology

26
Q

Gram stain and culture Required Tube Type

A

Sterile sodium heparin or sodium
polyanethol sulfonate

27
Q

Cell counts Required Tube Type

A

Sodium heparin or liquid ethylenediaminetetraacetic acid
(EDTA)

28
Q

Glucose analysis Required Tube Type

A

Sodium fluoride or nonanticoagulated

29
Q

Glucose analysis Required Tube Type

A

Sodium fluoride or nonanticoagulated

30
Q

Type 2 classification

A

Inflammatory

31
Q

Type 3 group classification

A

Septic

32
Q

Group 4 classification

A

Hemorrhagic

33
Q

The color becomes a deeper yellow in the presence of

A

noninflammatory and inflammatory effusions

34
Q

The color may have a greenish tinge with

A

Bacterial infection

35
Q

vacuolated noninflammatory and inflammatory effusions

A

Neutrophages

36
Q

neutrophils with small, dark cytoplasmic granules

A

Ragocytes

37
Q

hemosiderin granules are seen in cases of

A

pigmented villonodular synovitis

38
Q

The primary crystals seen in synovial fluid

A

monosodium urate (uric acid) (MSU), calcium pyrophosphate dihydrate (CPPD)

39
Q

Polymorphonuclear leukocyte

A

Neutrophil

40
Q

Significance of neutrophil

A

Bacterial sepsis, crystal induced inflammation

41
Q

Mononuclear leukocyte Nonseptic inflammation

A

Lymphocyte

42
Q
  • Large mononuclear leukocyte, may be vacuolated
  • normal and viral infections
A

Macrophage (monocyte)

43
Q

Similar to macrophage, but may be multinucle-
ated, resembling a mesothelial cell

A

Synovial lining cell

44
Q

Normal, disruption from arthrocentesis

A

Synovial lining cell

45
Q

Neutrophil containing characteristic ingested
“round body”

A

LE cell

46
Q

Vacuolated macrophage with ingested
neutrophils

A

Reiter cell

47
Q

Neutrophil with dark cytoplasmic granules
containing immune complexes

A

RA cell (ragocyte)

48
Q

Large, multinucleated cells

A

Cartilage cells

49
Q

Macroscopically resemble polished rice
Microscopically show collagen and fibrin

A

Rice bodies

50
Q

Refractile intracellular and extracellular globules
Stain with Sudan dyes

A

Fat droplets

51
Q

Inclusions within clusters of synovial cells

A

Hemosiderin