syndrome of inappropriate ADH (SIADH) Flashcards

1
Q

SIADH

A

inappropriately large amounts of ADH

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2
Q

what may cause SIADH

A

pos pituitary secreting too much
or
coming from elsewhere e.g. a small cell lung cancer

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3
Q

what does excessive AHD result in

A

excessive water reabsorption in CD
water dilutes sodium, resultin in hyponetreamia

urine becomes more concentrated as less water excreted

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4
Q

SIADH - what happens to sodium

A

euvolaemic hyponatraemia

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5
Q

SIADH - urine characteristis

A

high urine osmolality

high urine sodium

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6
Q

symptoms

A

headache
fatigue
muscle aches, cramps
confusion

severe hyponatraemia –> seizures, reduced conscioussness

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7
Q

causes

A
post-op 
infection 
head injury 
medications - thiazide diuretics, SSRIs, NSAIDs
malignancy esp SCLC 
meningitis
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8
Q

Mx

A
  • establish and treat cause
  • fluid restriction
  • ADH receptor blockers
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9
Q

central pontine myelinolysis

A

CPM (osmotic demyelination syndrome) –> complication of severe hyponatraemia being treated too quickly

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