cushing's Flashcards

1
Q

cushing’s syndrome

A

signs and symptoms after prolonged abnormal cortisol elevation

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2
Q

cushing’s disease

A

pituitary adenoma secretes excessive ACTH

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3
Q

cushing’s syndrome features

A
moon face
central obesity 
abdo striae
buffalo hump 
proximal limb wasting 
htn 
cardiac hypertrophy 
hyperglycaemia (T2DM) 
depression 
easy bruising 
osteoporosis
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4
Q

causes of Cushing’s syndrome

A

exogenous steroids
Cushing’s disease
adrenal adenoma
paraneoplastic cushing’s

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5
Q

dexamathasone suppression test

A

dose of dexamethasone at night –> cortisol and ACTH measured in morning –> does dexamethasone suppress normal AM cortisol spike

do low dose –> if normal cuhsing’s excluded, if abnormal do high dose to differentiate between causes

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6
Q

high dose dexamethasone suppresion test results: pituitary adenoma

A

low cortisol and ACTH

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7
Q

high dose dexamethasone suppresion test results: adrenal adenoma

A

cotrisol normal

ACTH low

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8
Q

high dose dexamethasone suppresion test results: ectopic ACTH (paraneoplasitc)

A

cortisol and ACTH normal

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9
Q

Mx

A

remove underlying cause

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