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Neuro I > Synaptic Transmission In the CNS > Flashcards

Synaptic Transmission In the CNS Flashcards

1
Q

Mechanism for plasticity

A

mean quantile content of 0.5 compares to NMY with 1

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2
Q

Name 2 glutamate receptors

Which cations

A

AMPA
NMDA

Na\K

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3
Q

AMPA role on Ca permeability

A

Decrease except in GluR-2

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4
Q

NMDA role in Ca permability

A

Increase

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5
Q

GluR-2 role in Ca permeability
Young
Old

A

Young: Increase Ca permeability

Older: Decrease Ca permeability

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6
Q

Neuronal Nicotinic AchR

  • Cations
  • Excitatory\Inhibitory
  • Which neurons
A

Cations: Na\K\Ca
Excitatory (fast)
Peripheral neurons

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7
Q

Purinergic receptors

  • Bind what?
  • Receptors of what?
A

ATP\adenosine

Pain & mechanosensory conduction

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8
Q

Name 2 inhibitory receptors and where located

A

GABA type A: Brain

Glycine receptors: Spinal cord

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9
Q

Changes in NKCC1
Young Neurons
Older Neurons

A

Young: Increase intracellular CL
Excitatory

Older neurons: Decrease Cl, inhibitory

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10
Q

Example of subunit heterogeneity: why is rat poison more toxic to adults?

A

Glycine inhibitory neurons have higher affinity for strychnine in adult versus young form

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11
Q

Examples of molecules that cause allosteric modulation of GABA receptors

A

Benzodiazepines
Alcohol
Anabolic steroids
Barbiturates

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12
Q

Temporal summation

A

Rapid succession of inputs from a single stimuli

Depends on time constant

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13
Q

Spatial summation

A

Rapid succession of inputs from separate stimuli

Depends on length constant

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14
Q

Desensitization

A

Differential desensitization of receptors, nACHR GABA desensitizes faster than glutamate
- role in memory

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15
Q

Facilitation Mechanism

A

Increase AP → Increase Ca multiple fibroadenoma Increase NT release

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16
Q

What does the influx of Ca do to dopaminergic neurons?

A

Increase dopamine release

17
Q

What does the influx of Ca do to GABA neurons?

A

Decrease GABA release

18
Q

Seritonergic (5-HT) neurons in the CNS are

A

G-protein metabotropic

19
Q

50% of neurons in the CNS are

A

Serotonergic

20
Q

A decrease in Seritonergic (5-HT) neurons is associated with

A

Decline in mental understanding, alzheimer’s

21
Q

Describe mesolimbic reward system

A
  1. Dopamine is released from Ventral Tegmental Area to neurons in the Nucleus Accumbens (NAc)
  2. Inhibitory GABA neurons, when stimulated will release less inhibitory (Ca releases decreases GABA release) GABA will be releases
22
Q

3 mechanisms for termination on NT

A
  1. Diffusion
  2. Reuptake
  3. Enzymatic degradation

Neuro I (10 decks)

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