Glial Biology

Question 1

Name the 3 big classes of glia & embryonic origin

Answer 1

1. Macroglia = Neuronal ectoderm
2. Microglia = Mesoderm
3. Schwann cells = Neural crest cells

Question 2

5 subtypes of macroglia

Answer 2

1. Astrocytes
2. Oligiodendrocytes
3. ependymal cells
4. Choroid plexus
5. Radial glia

Question 3

Function (astrocytes)

Answer 3

1. BBB
2. Regulate external K+
3. Produce extracellular matrix
4. Healing

Question 4

Role of astrocytes in the tripartite sinus

Answer 4

Glutamate recycling

Make\break a synapse

Question 5

Function: Olgiodendrocytes

Answer 5

Mylinate 10-14 axons

Question 6

Function: Choroid plexus

Answer 6

CSF production site, contains ependymal cells

Question 7

Function: Radial glia

Answer 7

Progenitors for macroglia

Question 8

Function: Ependymal cells

Answer 8

Produce CSF

Line ventricle and central canal

Question 9

Neuroinflammation is caused by (3)

Answer 9

Infection
MS
Degenerative disease that form plaques

Question 10

Name cells involved in neuroinflamation

Answer 10

Astrocytes
Microglia
Endothelial cells
Perivascular cells
Circulating immune cells

Question 11

Name mechanisms to control neuroinflamation

Answer 11

NSAID
Steroids
Antibiotics
Canabonoids
Vaccines
Cytokines