Morphogenesis Flashcards
Name 6 steps of neurolation
- Neuroplateo develops in mesoderm (18 days)
- Neural groove forms (20 days)
- Central canal forms (22 days)
- Sensory ganglia form (24 days)
- Closure of anterior & posterior neuropores
The central canal forms
Ventricular system
Sensory ganglia are derived from
Neural crest cells
Which molecule is important for the initiation of neurolation?
BMP
What inhibits BMP
Niggin, chordin & folistati
Sensory ganglia are derived from
Neural crest cells
Which molecule is important for the initiation of neurolation?
BMP
Which molecule is important for ventralization?
What produces the molecule?
Sonic Hedgehog
Notocord & floor plate
Which molecule is important for dorsalization?
What produces the molecule?
TGF-beta
BMP
Dorsain
Vitamin A
What induces floor plate formation?
Notocord
Alar plate
(motor or sensory)?
Sensory
Basal plate
(motor or sensory)?
Motor
Which molecule is responsible for setting rostral-caudal direction?
Retenoic Acid detemines caudal direction
Excess external retencacid is
fatal
Retinoic acid determines the expression of
HOX genes