Synaptic plasticity Flashcards
Pavlovian conditioning
Association between a neutral stimilus and a positive or negative stimulus.
Operant conditioning
Associating a voluntary behaviour with a concequence.
Tone-cued fear
Hippocampus independent, Amygdala dependent
Contextual fear
Hippocampus dependent, amygdala dependent.
The objects location memory task requires:
Hippocampus
The rotarod task requires:
Motor cortex and cerebellum
Anisomycin
Protein synsthesis inhibitor. New proteins are the essential building blocks to strengthen neuronal connections
Protein synthesis is required for:
Making new axonal-dendritic connections
Strengthening existing connections
Synaptic plasticity
Process of making new connections and/or changing the strength of existing connections.
Long-term potentation (LTP)
Form of synaptic plasticity and the molecular basis of memory storage.
E-LTP
A weak form of learning that is not persistent. (Short-term memory that is not consolidated into long-term memory)
EPSP
Measure of relative strength of the neuronal connections before and after stimulation
L-LTP
A strong form of learning that is persistent (Short-term memory that is succesfully consolidated into long-term memory)
NMDA receptors
Essential for LTP induction and the initiaition of memory formation.
Cofilin
Protein that breaks down spines when it is activated. (highly activated in sleep-deprived hippocampus)