Cholinergic system/Alzheimer's Disease Flashcards
Modulatory systems
- serotonine
- dopamine
- noradrenaline
- acetylcholine
The essence of learning and memory:
strengthening of synaptic contacts
The cholinergic system is crucial for:
Attention and the starting point of a learning process
Acetylcholine is made from:
Choline and acetyl CoA
Function of the enzyme acetylcholinesterase
Breaks down Ach in the synaptic cleft
The two types of cholinergic receptors:
- Nicotinic receptor
2. Muscarinic receptor
Social contacts and stressfull event play a role in ….
The formation of alzheimers disease
Tau protein
Anchors the mircotubules, when the proteins are gone the entire structure of the cell collapses.
Extracellular amyloid plaques
Consisting of amorphous extra cellular deposists of aß protein. Outside the neuron
Neurofibrillary tangles
Comprising of filaments of phosphorylated Tau protein, Inside the neuron.