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Step 1 Pharmacology > Sympathomimetics > Flashcards

Sympathomimetics Flashcards

1
Q

What receptors does Epinephrine affect?

A

β > α

α effects predominate at high doses

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2
Q

What receptors does Norepinephrine affect?

A

α1 > α2 > β1

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3
Q

What receptors does Isoproterenol affect?

A

β1 = β2

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4
Q

What receptors does Dopamine affect?

A

D2 = D2 > β > α

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5
Q

What receptors does Dobutamine affect?

A

β1 > β2,α

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6
Q

What receptors does Phenylephrine affect?

A

α1 > α2

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7
Q

What receptors does Albuterol, Salmeterol, and Terbutaline affect?

A

β2 > β1

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8
Q

What are the applications of Epinephrine?

A

Anaphylaxis, open angle glaucoma, asthma, hypotension

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9
Q

What are the applications of Norepinephrine?

A

Hypotension (but ↓ renal perfusion)

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10
Q

What are the applications of Isoproterenol?

A

Electrophysiologic evaluation of tachyarrhythmias ; can worsen ischemia

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11
Q

What are the applications of Dopamine?

A

Unstable bradycardia, heart failure, shock; inotropic and chronotropic α effects predominate at high doses

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12
Q

What are the applications of Dobutamine?

A

Heart failure (inotropic > chronotropic), cardiac stress testing

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13
Q

What are the applications of Phenylephrine?

A

Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant)

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14
Q

What are the applications of Albuterol, Salmeterol, and Terbutaline?

A

Albuterol for acute asthma; salmeterol for long-term asthma or COPD control; terbutaline to reduce premature uterine contractions

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15
Q

Indirect sympathomimetics - What are the effects of Amphetamines?

A

Indirect general agonist, reuptake inhibitor, also releases stored catecholamines

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16
Q

Indirect sympathomimetics - What are the effects of Ephedrine?

A

Indirect general agonist, releases stored catecholamines

17
Q

Indirect sympathomimetics - What are the effects of Cocaine?

A

Indirect general agonist, reuptake inhibitor

18
Q

Indirect sympathomimetics - What are the applications of Amphetamines?

A

Narcolepsy, obesity , ADD

19
Q

Indirect sympathomimetics - What are the applications of Ephedrine?

A

Nasal decongestion, urinary incontinence, hypotension

20
Q

Indirect sympathomimetics - What are the applications of Cocaine?

A

Causes vasoconstriction and local anesthesia; never give β-blockers if cocaine intoxication is suspected (can lead to unopposed α1 activation and extreme hypertension)

Step 1 Pharmacology (18 decks)

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