Sympathetic system- lecture 9

Question 1

What are the 2 main receptors for the sympathetic nervous system?

Answer 1

noradrenaline NA and adrenaline A (epinephrine is the another name for adrenaline)

Question 2

Explain the half lives of NA and A and how the body will deal with this?

Answer 2

The reactive process is important for their half lives, this occurs natural in the body You want to resevere it not break it all down and synthesis it all again There is re-uptake in the vesicles

Question 3

How do the following drugs effect the levels of NA or NE

Answer 3

tyramine and amphetamine will enhance the NA release Bretylium stops the NE release

Question 4

Explain the effect of alpha and beta receptors on NA and A

Answer 4

Alpha receptors will stimulate A and NA Beta receptors will block NA and therefore will stimulate parasympathetic nervous system

Question 5

For beta 1 receptors state location effects drugs to use antagonist

Answer 5

Beta 1 receptors; beta 1; 1 heart

• located in the heart and some in the kidney and their are very sensitive to hypoxia
• effects increase cardiac output increase force and rate of contraction increase BP
• drugs to use to increase this Isoproterenol (most selective and best to use) E NE
• antagonist (inhibitor of these effects); propranolol atenolol

Question 6

get photo

Answer 6

get photo

Question 7

For Beta 2 state location effects drugs to use

Answer 7

Beta 2; beta 2, 2 lungs

• location; wide distributed, lungs, smooth and skeletal muscle, hepatocyte
• effects increase gaseous exchange relax muscles bronchodilation
• useful for asthma
• drugs to use toe increase this effect Isoproterenol (most selective and best to use) E NE

Question 8

Answer the following

Answer 8

want to stimulate beta 2 receptors (B and D)

Question 9

For Alpha 1 receptors state location effects

Answer 9

Alpha 1 receptors;

• location; widely distributed but mostly in the blood and spinster of the vital organs
• effects stimulate sympathetic response and will constrict the bladder (smooth muscle contraction think of a noose) construction of blood vessels and redirection of blood to help you run away

Agonists; NA, adrenaline, Isoproterenol