Sympathetic Nervous System

Question 1

What does Monoamine Oxidase (MAO) do?

Answer 1

Enzyme responsible for breaking down norepinephrine.

Question 2

What happens when we inhibit Monoamine Oxidase (MAO)?

Answer 2

We will be increasing norepinephrine levels

Question 3

What are the mechanisms that can indirectly increase or decrease the sympathetic response include actions on…

Answer 3

• Synthesis
• Storage
• Release
• Uptake/Reuptake
• Receptor

Question 4

What percentage of neurotransmitter is recycled back up into the pre-synaptic ganglia?

Answer 4

85%

Question 5

Is a sympathetic agonist or antagonist used to treat the following:

• Cardiac disease
• Anaphylactic/anaphylactoid reactions
• Obstructive airway disease
• Sedation/analgesia

Answer 5

Agonists

Question 6

Is a sympathetic agonist or antagonist used to treat the following:

• To treat tachyarrhythmias
• Vasodilation
• Reversal of alpha-2 sedation

Answer 6

Antagonists

Question 7

What are some negative effects of Catecholamines in general?

Answer 7

• can predispose to arrhythmias/tachycardia
• anxiety, restlessness, tremors
• cerebral hemorrhage
• too much vasoconstriction, resulting in too little perfusion to kindneys

Question 8

What are the three endogenous substances that are produced by the body?

Answer 8

• Epinephrine
• Norepinephrine
• Dopamine

Question 9

Are epinephrine, norepinephrine, and dopamine “TRUE CATECHOLAMINES”?

Answer 9

YES

Question 10

Do Catecholamines have a low or high 1st pass effect?

Answer 10

HIGH

Question 11

Where are catecholamines readily absorbed?

Answer 11

RESPIRATORY

Question 12

ALPHA-1:

Answer 12

works on vasculature

-VASOCONSTRICTION

Question 13

BETA-1:

Answer 13

Act on heart

• INCREASE CONTRACTILITY
• INCREASE HR to some degree

Question 14

BETA-2:

Answer 14

BRONCHODILATION

-some vasodilation