ParasympathoLYTICS

Question 1

What do parasympatholytics do?

Answer 1

act as muscarinic antagonists, preventing the actions of acetylcholine at PSNS target tissues

Question 2

Atropine

Answer 2

It’s major actions are antimuscarinic:

• Dry secretions (including salivation)
• Slow the GI tract
• Increase heart rate
• Dilate the airways
• Dilate the pupils

Question 3

Atropine should not be used in….

Answer 3

Glaucoma or pre-existing tachycardia

Question 4

Caution using atropine in….

Answer 4

HORSES

Question 5

Glycopyrrolate

Answer 5

• slower onset and longer duration of action than atropine
• gradual effect, not like dramatic effect w/ atropine
• Used on p under for SX
• Preferred over atropine for rabbits
• Can be used for excessive drooling (not common)

Question 6

Oxybutynin AND Propantheline

Answer 6

• Urinary ‘antispasmodic’
• Direct antimuscarinic and spasmolytic effects on smooth muscle, particularly bladder and large intestine
• TX for overactive bladder