Sympathetic Nervous System Flashcards

1
Q

Other term for Sympathetic Nervous System

A

ADRENERGIC System

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2
Q

System Responsible for arousing and adrenaline rush or “FIGHT or Flight” response

A

Sympathetic Nervous System

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3
Q

NEUROTRANSMITTER of SNS

A

Norepinephrine, Epinephrine

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4
Q

Receptors of SNS

A

Alpha
Beta
Dopamine

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5
Q

It is the primary neurotransmitter of
postganglionic sympathetic adrenergic
nerves

A

Norepinephrine

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6
Q

Norepinephrine is released by the nerve when an ________ travels down the nerve

A

Action potential

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7
Q

Norepinephrine is synthesized inside nerve axon in the __________ and stored within _______

A

Adrenal medulla
Vesicles

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8
Q

What are the fates of Norepinephrine

A

Biosynthesis
Release
Binding to receptor (α, β and D)
Metabolism (30% inactivation)– MAO & COMT
Reuptake (70% of inactivation

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9
Q

facilitates the entry of tyrosine

A

Sodium (Na+)

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10
Q

facilitates the release of neurotransmitter

A

Calcium (Ca+2)

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11
Q

considered as “rate-limiting step”

A

catalyzed by tyrosine hydroxylase

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12
Q

Responsible for 70% of inactivation

A

REUPTAKE

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13
Q

Responsible for 30% of inactivation

A

METABOLISM

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14
Q

Steps in Epinephrine Biosynthesis (Lowest -Highest)

A

Tyrosine
DOPA
Dopamine
Norepinephrine
Epinephrine

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15
Q

DOPA-Dopamine is catalyzed by ______

A

dopa decarboxylase

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16
Q

Dopamine– Norepinephrine is catalyzed by ______

A

dopamine-b-hydroxylase (Addition of (OH) group in C2/ beta carbon)

17
Q

NE– Epinephrine is catalyzed by _________

A

Phenyl ethanolamine-N-methyltransferase (PENMT)

18
Q

Reuptake is facilitated by __________

A

Norepinephrine transporter (NET)

19
Q

Responsible for Phase 1 metabolism/oxidation

A

Monoamine oxidase (MAO)

20
Q

Responsible for Phase 2 / methylation

A

Catechol-O-methyltransferase ( COMT)

21
Q

This final product is measured in urine and plasma in the diagnosis of pheochromocytoma

A

Vanillylmandelic acid (VMA)