Drugs for Mood Disorders 2

Question 1

Treatment for seizure caused by TCAs

Answer 1

Diazepam

Question 2

When given to normal non-depressed subjects they increase a motor activity and cause euphoria + excitements (risk of abuse)

Answer 2

Monoamine oxidase Inhibitors

Question 3

MAO found in the liver, gastrointestinal tract, and placenta

Answer 3

MAO-A

Question 4

MAO mostly found in blood platelets.

Answer 4

MAO-B

Question 5

MAO-B metabolizes ___________

Answer 5

Dopamine (DA)

Question 6

MAO that are Irreversible non-selective (MAOA and MAOB) inhibitors

Answer 6

Hydrazines

Question 7

How long do Hydrazines last?

Answer 7

1-2 weeks

Question 8

Examples of Hydrazines

Answer 8

Phenelzine (Nardil)
Tranylcypromine (Parnate)
Isocarboxacid

Question 9

MAO that are Reversible Inhibitors of MAO-A (RIMA)

Answer 9

Non-hydrazines

Question 10

Example of Non-hydrazines

Answer 10

Moclobemide (Aurorix)

Question 11

MAO that are Reversible inhibitors of MAO-B

Answer 11

MAO B-selective

Question 12

MAO B-selective are used to treat ____________

Answer 12

Parkinson’s disease

Question 13

Example of MAO B-Selective

Answer 13

Selegiline

Question 14

MAOIs are reserved for ______________

Answer 14

Atypical depression
Refractory to other antidepressants

Question 15

Adverse Effects of MAOIs

Answer 15

Orthostatic hypotension
Weight gain/ increased appetite
Anorgasmia
Discontinuation syndrome