Sx Cushing Flashcards

1
Q

Sx cushing

A

Es un exceso de cortisol de causa patológica clínica

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2
Q

Enfe.cushing

A

Causa más común sx Cushing endógeno

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3
Q

Aldosterona

A

Reabsorbe sodio
Secreta potasio

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4
Q

Médula se produce

A

Catecolaminas

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5
Q

Causas que provocan ACTH exógenas

A

Cancer de pulmón de células pequeñas
Tumores neuroendocrino (páncreas y timo)

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6
Q

Clínica

A

Miopatia proximal
Pletora facial

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7
Q

Pruebas

A
  1. Medición cortisol orina 24 hrs

2 . Prueba de supresión con dosis bajas de deametazona

  1. Medición cortisol saliva nocturno

Necesita 2 pruebas

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8
Q

Falsos negativos cortisol en orina

A

Tasa de filtrado baja
TFG menor 60
Cushing leve

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9
Q

Test de supresión con dexa falsos negativo s

A

Renal

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10
Q

Falsos negativos en cortisol saliva nocturno

A

Trabajar nocturno

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11
Q

Dx

A

1.corrobar que tenga cortisolismo 3 pruebas

1(+) repetir o pedir recolección de 24 hrs orina

  1. Ver si e dependiente o independiente
    Independiente ACTH BAJA
    Dependiente es sx cushing o (hacer prueba con dexametazona)
    Par hacer el dx diferencial cushing o adenoma con dosis altas dexametazona si es hipofisiario o ectopico
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12
Q

ACTH independiente

A

Hacer TAC

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13
Q

Tratamiento primera línea

A

Resección tranesfenoidal

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14
Q

Inhiben el cortisol

A

Ketoconazol
Metyrapona

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15
Q

La causa más común de hipercotisolismo endógeno es la enfermedad cushing

A
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16
Q
A

Mifepristona