suspensions Flashcards
Acacia
Hydrophilic Colloids
Tragacanth
Hydrophilic Colloids
Celluloses
Hydrophilic Colloids
Acacia ideal concentration:
5-15%
What is acacia made from?
Extract from acacia tree
Does Acacia need preservatives?
Yes!
Name two preservatives used to preserve acacia?
Sodium Benzoate for Oral Suspensions
Benzalkonium Chloride for external suspensions
What % of alcohol is incompatible with acacia
30% of alcohol
Tragacanth is extracted from?
Gummy exudate from the gum tree
What is tragacanth similar to?
Similar to acacia
Does tragacanth need preservative?
Yes
What % alcohol is tragacanth incompatible with?
30% alcohol
Name 4 Celluloses
Hydroxyethycellulose
Sodium carboxymethylcellulose
Methylcellulose
Hydroxypropylmethylcellulose
Hydroxyethycellulose?
Suspending Agent
What concentration is Hydroxyethycellulose used in?
0.5% w/v
Hydroxyethycellulose can be used in which solutions? pH wise.
High Acid and alkaline
True or False: Hydroxyethycellulose has few incompatibilities
True.
What can Hydroxyethycellulose dissolve in (temp. wise)
hot and cold water
T/F: Sodium carboxymethylcellulose is as good as hydroxyethycellulose
False. Not as good.
Why is sodium carboxymethylcellulose not as good as hydroxyethycellulose?
Has a significant amount of incompatibilities & can’t be used with any acids
What concntration is sodium carboxymethylcellulose used in?
0.5-4% w/v
Methylcellulose brand names
Methocel-R and Cellothyl-R
Is Methylcellulose soluble in hot water?
NO.
What water temperature is methyl cellulose soluble at?
Cold or refrigerated water
What happens when you place methyl cellulose at room temperature?
It forms clumps that can eventually dissolve.
What concentration is methyl cellulose used at?
1-2%
Is hydroxypropylmethylcellulose soluble in water?
Insoluble in water above 45 F
What concentration is hydroxypropylmethylcellulose used at?
0.5-1%
Two types of clays
Bentonite and Veegum
Bentonite: for internal or external use?
External only.
Does Bentonite dissolve in water?
It does not. But it can absorb 12 x its own volume
What is bentonite incompatible with?
Alcohol and in acidic pHs
does bentonite require a preservative?
Yes. Requires a preservative
What concentration is Bentonite used in?
2% w/v
Can Veegum be used internally or externally?
Internally.
What is veegym incompatible with?
In acidic pHs and alcohols
Does veegum require a preservative?
Yes
What conc. % is veegum used in?
2& w/v
