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pharmaceutics II > suspensions > Flashcards

suspensions Flashcards

1
Q

Acacia

A

Hydrophilic Colloids

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2
Q

Tragacanth

A

Hydrophilic Colloids

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3
Q

Celluloses

A

Hydrophilic Colloids

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4
Q

Acacia ideal concentration:

A

5-15%

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5
Q

What is acacia made from?

A

Extract from acacia tree

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6
Q

Does Acacia need preservatives?

A

Yes!

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7
Q

Name two preservatives used to preserve acacia?

A

Sodium Benzoate for Oral Suspensions
Benzalkonium Chloride for external suspensions

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8
Q

What % of alcohol is incompatible with acacia

A

30% of alcohol

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9
Q

Tragacanth is extracted from?

A

Gummy exudate from the gum tree

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10
Q

What is tragacanth similar to?

A

Similar to acacia

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11
Q

Does tragacanth need preservative?

A

Yes

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12
Q

What % alcohol is tragacanth incompatible with?

A

30% alcohol

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13
Q

Name 4 Celluloses

A

Hydroxyethycellulose
Sodium carboxymethylcellulose
Methylcellulose
Hydroxypropylmethylcellulose

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14
Q

Hydroxyethycellulose?

A

Suspending Agent

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15
Q

What concentration is Hydroxyethycellulose used in?

A

0.5% w/v

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16
Q

Hydroxyethycellulose can be used in which solutions? pH wise.

A

High Acid and alkaline

16
Q

True or False: Hydroxyethycellulose has few incompatibilities

A

True.

17
Q

What can Hydroxyethycellulose dissolve in (temp. wise)

A

hot and cold water

18
Q

T/F: Sodium carboxymethylcellulose is as good as hydroxyethycellulose

A

False. Not as good.

19
Q

Why is sodium carboxymethylcellulose not as good as hydroxyethycellulose?

A

Has a significant amount of incompatibilities & can’t be used with any acids

20
Q

What concntration is sodium carboxymethylcellulose used in?

A

0.5-4% w/v

21
Q

Methylcellulose brand names

A

Methocel-R and Cellothyl-R

22
Q

Is Methylcellulose soluble in hot water?

A

NO.

23
Q

What water temperature is methyl cellulose soluble at?

A

Cold or refrigerated water

24
Q

What happens when you place methyl cellulose at room temperature?

A

It forms clumps that can eventually dissolve.

25
Q

What concentration is methyl cellulose used at?

A

1-2%

26
Q

Is hydroxypropylmethylcellulose soluble in water?

A

Insoluble in water above 45 F

27
Q

What concentration is hydroxypropylmethylcellulose used at?

A

0.5-1%

28
Q

Two types of clays

A

Bentonite and Veegum

29
Q

Bentonite: for internal or external use?

A

External only.

30
Q

Does Bentonite dissolve in water?

A

It does not. But it can absorb 12 x its own volume

31
Q

What is bentonite incompatible with?

A

Alcohol and in acidic pHs

32
Q

does bentonite require a preservative?

A

Yes. Requires a preservative

33
Q

What concentration is Bentonite used in?

A

2% w/v

34
Q

Can Veegum be used internally or externally?

A

Internally.

35
Q

What is veegym incompatible with?

A

In acidic pHs and alcohols

36
Q

Does veegum require a preservative?

A

Yes

37
Q

What conc. % is veegum used in?

A

2& w/v

pharmaceutics II (6 decks)

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