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pharmaceutics II > suppositories > Flashcards

suppositories Flashcards

1
Q

What are two base types for suppositories?

A

Oleaginous and Water soluble

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2
Q

What is the common name for Theobroma Oil?

A

Cocoa Butter

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3
Q

What type of base is Theobroma Oil

A

Oleaginous Base

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4
Q

Physical Characteristics of Theobroma Oil

A

Yellowish-White solid with an odor of chocolate

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5
Q

What is theobroma oil a mixture of?

A

glyceryl esters of unsaturated fatty acids

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6
Q

Advantages of using theobroma oil as stated in the slides

A

At room temperature it is solid, and at 86-95 degrees (body temperature), it melts to a bland and non-irritating oil

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7
Q

What are some things we need to consider when we’re formulating a suppository with theobroma oil?

A

It cannot be heated above 35 degrees celsius because it will convert into a different structure that then has a much lower melting point (25-30 degrees)

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8
Q

Some drugs may lower the melting point of theobroma oil. What can we do to combat this?

A

Add in spermaceti, or beeswax to raise the melting point

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9
Q

Synthetic Triglycerides- common name

A

Hydrogenated Vegetable Oils

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10
Q

What is an advantage of using Synthetic triglycerides over theobroma oil?

A

It does not exhibit polymorphism. This means that even if heated to 35 degrees Celsius, it will not convert to another form that then has a lower melting point/

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11
Q

What is an disadvantage of using Synthetic triglycerides over theobroma oil?

A

it’s more expensive

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12
Q

Name brands for Synthetic triglycerides

A

Fattibase® , Wecobee®, Dehydag®, Hydrokote®, Suppocire®, and Witepsol®.

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13
Q

Glycerinated Gelatin

A

Water Soluble / Water Miscible base

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14
Q

Physical attributes of glycerinated gelatin

A

Translucent, resilient, gelatinous solids

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15
Q

Action of glycerinated gelatin as a base?

A

They tend to dissolve and disperse slowly in mucous secretions to provide a prolonged release of active ingredients

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16
Q

What is glycerinated gelatin made of?

A

Glycerol, gelatin and water.

17
Q

How should glycerinated gelatin be stored?

A

well-closed containers in a cool place since they absorb and dissolve in atmospheric moisture.

18
Q

If we want to create a suppository with glycerinated gelatin as the base, and we want it to have an extended shelf life, what should we add to it?

A

A preservative

19
Q

What needs to be done to gelatin suppositories just before use?

A

Dipped in water.

20
Q

Polyethylene Glycol Polymer base type

A

Water Soluble/Water Miscible Bases

21
Q

Properties of Polyethylene Glycol Polymers:

A

Chemically stable, nonirritating, miscible with water

22
Q

Advantages of formulating with Polyethylene Glycol Polymers:

A

Can be formulated by molding or compression
Can also be used to make a wide variety of hardness (soft-hard suppositories) and melting point

23
Q

Does glycerinated gelatin or polyethylene glycol polymers melt at body temperature?

A

They do not.

24
Q

If glycerinated gelatin or polyethylene glycol polymers don’t melt at body temp, how are they released in the body?

A

They are released after dissolving in bodily fluids and mucous secretions the body

25
Q

Which provides a more prolonged release: Theobroma Oil or Polyethylene glycol polymers?

A

Polyethylene glycol polymers.

Makes sense b/c it does not melt at body temperature

26
Q

Commonly, do formulas call for Polyethylene glycol polymers by themselves as a base, or in combination?

A

Usually asks for combination. Formulas will ask for compounds of two or more molecular weights to get the desired hardness and dissolution time

27
Q

Because glycerinated gelatin or polyethylene glycol polymers (just water miscible suppsoitories in general) don’t have to melt at body temperature, what makes this advantageous?

A

They can be formulated with much higher melting points (dont need to melt @ body temp), and can safely be stored at room temperature

28
Q

Hand Rolling method

A

Is used to prepare a small number of suppositories

Kind of like making dough. Roll out a log of the suppository and cut it to size

29
Q

Compression Molding

A

Cold mass of base that contains the drug is compressed using a hand operated machine

30
Q

Fusion Molding

A

First melting the suppository base & then dispersing the drug in the melted base. Mixture can then be removed from the heat and then poured into the suppository mold, and once it congeals, it is removed from the mold.

31
Q

Automatic Molding Machine

A

All operations are done by automatic machines. Using the machine, 10,000 suppositories can be made per hour

32
Q

Shape of a suppository mold

A

Bullet shaped

pharmaceutics II (6 decks)

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