Surgery Drugs Flashcards
anti-coagulant mechanism
prolong clotting time
unfractionated heparin, Lovenox, and Coumadin are what kind of drug
anticoagulant
antiplatelet mechanism
decrease platelet aggergation, inhibit thrombus formation
eliquis, pradaxa, xarelto: what kind of drug
direct anticouags (inhibit Xa or thrombin)
what drugs don’t need bridge therapy?
DOAC (eliquis, pradaxa, xarelto)
when to stop ibuprofen before surgery
1 day
when to stop NSAID, COXII inhibitor, DOACs?
2-3 days before
when to stop ASA (aspirin)?
7-10d
when to stop plavix and warfarin?
5 days (plavix up to 7d)
for a VTE risk procedure… when to stop OCP/HRT?
4-6 weeks
warfarin reversal agent
vitamin K
pradaxa reversal agent
praxbind
what meds might require bridge therapy?
when is bridge therapy approrpriate?
warfarin, plavix
approp when anticogulation outside therapetuic range
clindamycin covers
gram +, anaroebes, MRSA
PCNs cover
gram +
cephalosporins cover
gram +
Augmentin covers
gram + (broad), anaroebes
Zosyn (piptazo) covers
gram +, gram -, anaroebes
cipro covers
gram -, pseudomonas
gentamycin
gram -, ESCAPMM
cefurozime ceftriazone ceftazidime cefepime cover
gram -
metronidazole covers
anaroebes
moxifloxacin covers
anaroebes
levofloxacin covers
psuedomonas
ceftazidime, cefepime cover
gram -, anarobes
tobramycin covers
gram -, ESCAPMM, psuedomonas
-penems cover
psuedomonas, gram -, gram +, ESCAPMM
linzolid covers
MRSA, G+, G-
vancomycin covers
G+, MRSA
doxycycline and minocycle cover
G+, MRSA
bactrim covers
G+, MRSA
cefazolin IV and clindamycin IV for what type of surgery
CLEAN
does clean surgery always need abx?
no
cefazolin + metronidazole together for what type of surgery
clean-contam
cefoxitin/cipro/levo + metronidazole for what type of surgery
contaminated
clindamycin + gentamicin for what type of surgery
contaminated
aztreonam for what type of surgery
contaminated
fluroquinolone for what type of surgery
contaminated
zosyn (piptazo) for what type of surgery
dirty
meropenem for what type of surgery
dirty
invanz for what type of surgery
dirty
unasyn for what type of surgery
dirty
primaxin for what type of surgery
dirty
timentin for what type of surgery
dirty
cefoxitin or what type of surgery
GI
cefoteten for what type of surgery
GI
clindamycin + aminoglycoside for what type of surgery
GI
surgical infection ppx - 3 options
piptazo
cefazolin
cefoxitin
abdominal surg ppx - 2 options
ampicillin/sulbactam
ceftraizone + metronidazole
endocarditis ppx
cefazolin
pneumocystis PNA ppx
bactrim
allogenic bone transplant ppx
fluconazole
etomidate effect
sedation (no analgesia)
ketamine effect
analegesia, amnesia, sedation
thiopental effect
sedation
propofol effect
sedation, amnesia (no analgesia!)
propofol contraindicated if you are…
hypOtensive
fentanyl effect
sedation