Clin Med - Endo

Question 1

most abundant cell of ant pituitary

Answer 1

somatotrophs, secrete GH

Question 2

hormones produced by ant pit

Answer 2

ACTH, FSH, GH ,LH, PRL, TSH (peptides)

FAT GLP

Question 3

hormones produced by hypothalamus

Answer 3

GHrH, GHiH, GnRH, PiF, TRH (peptides - PiF)

Question 4

hormones produced by post pit

Answer 4

ADH, oxytocin (peptides)

Question 5

hormones produced by adrenal medulla

Answer 5

epi, norepi (amines)

Question 6

hormones produced by adrenal cortex

Answer 6

cortisol, aldosterone (steroids)

Question 7

pituitary adenoma

Answer 7

high GH, PRL, low TSH, ACTH, GnT

Question 8

prolactin suppressed by

Answer 8

dopamine (produced by hypothalamus)

Question 9

GH 3 actions

Answer 9

glucose for brain (can raise plasma glucose)
AA uptake by muscle
fat as main energy source

Question 10

GH primarily released what time of day

Answer 10

night

Question 11

Persistently high GH can result in what other endocrine dz

Answer 11

diabetes (starts w insulin resistance)

Question 12

ACTH bursts MC what time of day

Answer 12

morning

Question 13

where to glucocorticoids bind w/in the cell

Answer 13

GRE on DNA

Question 14

low intrarenal arterial pressure and hyperkalemia trigger ___ release

Answer 14

aldosterone

Question 15

21 hydroxylase deficiency clinical picture

Answer 15

virilization, low cortisol/aldosterone

Question 16

thick oily skin, cardiomegaly, DM

Answer 16

GH excess (acromegaly, gigantism)

Question 17

if you give glucose you expect GH to

Answer 17

go down

Question 18

post-partum hypopituitarism d/t ischema

Answer 18

Sheehan syndrom

Question 19

lack of ADH, polyuria, polydipsia

Answer 19

diabetes insipdus

Question 20

glomerosa of adrenal gland produces

Answer 20

mineralcorticoids

Question 21

adrenal fasculata and reticularis produces

Answer 21

glucocorticooids, sex steroids

Question 22

adrenal medulla produces

Answer 22

catecholamines

Question 23

when to remove an adrenal nodule

Answer 23

> 6cm, funcitonally active

Question 24

seratonin stimulates

Answer 24

glucocorticoid production

Question 25

hypoK, hypergly, alkalosis, obesity, purple striae

Answer 25

Cushings (glucocorticoid excess)

Question 26

dehydr, low Na, high K, acidosis

Answer 26

glucocorticoid deficiency

Question 27

low cortisol and aldosterone, high ACTH leading to bronzing of skin

Answer 27

Addisons dz

Question 28

urine VMA important to dx

Answer 28

pheochromocytoma, neuroblastoma (tumor of adrenal medulla)

Question 29

if you find a cancer in the adrenal glands, is it more likely primary or secondary

Answer 29

primary

Question 30

when kid is > __ SD below NL, investigate GH

Answer 30

2.5

Question 31

HA, visual field deficit, libido dec.

Answer 31

prolactinoma

Question 32

tx: prolactinoma

Answer 32

dopamine agonist (bromacriptine)

Question 33

what’s a glucose suppression test

Answer 33

give glucose to suppress GH, if ineffective, suspect adeoma

Question 34

what does somatostatin do to GH

Answer 34

prevents its release

Question 35

MEN1 inheritance pattern

Answer 35

autosomal dom

Question 36

MEN1 3 P tumors

Answer 36

pit adenoma
PTH adenome
pancreatic tumor (insulinoma/gastrinoma)

Question 37

sx like pituitary adenoma, then sudden onset HA, visual loss, AMS, etc

Answer 37

pituitary apoplexy

Question 38

pit apoplexy tx

Answer 38

IV dexamethasone, transphenoidal surg

Question 39

euvolemic, hyponatremic w/ excess sodium in urine

Answer 39

SIADH