SUPPOSITORY BASE EXAMPLES

Question 1

Aka Theobroma oil

Answer 1

Cocoa butter

Question 2

Roasted seeds of Theobroma cocoa (fam. Sterculiaceae)

Answer 2

Cocoa butter

Question 3

Most stable polymorph of cocoa butter

Answer 3

Beta (34.5° C)

Question 4

B-prime polymorph cocoa butter temp

Answer 4

28°C

Question 5

A-polymorph cocoa butter temp

Answer 5

22°C

Question 6

G-polymorph cocoa butter temp

Answer 6

18°C

Question 7

Triglycerides present in cocoa butter

Answer 7

oleoPalmistostearin
oleoStearin

Question 8

_ and _ can DECREASE cocoa butter’s MP when incorporated with it

Answer 8

Phenol and Chloral hydrate

Question 9

Triglycerides from coconut oil

Answer 9

Wecobee

Question 10

Triglycerides from saturated fatty acid C12-C100

Answer 10

Witepsol

Question 11

Major saturated fatty acid of witepsol

Answer 11

Lauric acid

Question 12

Hydrogenated fatty acids of vegetable oils

Answer 12

Palm Kernel Oil
Cottonseed Oil

Question 13

Containing compounds of glycerin

Answer 13

Palmitic acid
Stearic acid

Question 14

Most frequently used in
preparation of vaginal
suppositories

Answer 14

Glycerinated gelatin

Question 15

Slower to soften & mix w/ the
physiologic fluids

Answer 15

Glycerinated gelatin

Question 16

Hygroscopic

Answer 16

Glycerinated gelatin

Question 17

Components of glycerinated gelatin

Answer 17

70% glycerin + 20% gelatin

Question 18

Polymers of ethylene oxide &
water

Answer 18

Polyethylene glycol

Question 19

Carbowax

Answer 19

Polyethylene glycol

Question 20

do not melt at body temperature but rather dissolve slowly in the body’s fluid

Answer 20

Polyethylene glycol

Question 21

For vaginal administration

Answer 21

Polyethylene glycol

Question 22

Water-soluble block co-polymers

Answer 22

Poloxamers

Question 23

Pluronic

Answer 23

Poloxamers

Question 24

A surface-active agent that is employed in a number of commercial suppository base

Answer 24

Polyoxyl 40 stearate