Suppositories Flashcards
suppositories
medicated, solid bodies of various weights/shapes intended for insertion into body cavities (rectal, vaginal, urethral)
- melt/soften/dissolve at body temp
- may be used for local/systemic effect
when should you compound suppositories
as a last resort due to difficulty compounding and unpredictable absorption
avoid suppositories with a ______
narrow therapeutic window
who are suppositories best for?
patients who are NPO and avoiding IV access
ideal properties of suppository base
- stable
- nonreactive with drugs/auxilary agents
- aesthetically pleasing
- melt/dissolve in body cavity
- nontoxic/nonirritating
- nonbinding with drugs
- viscous enough for drug suspension — thin enough to pour into mold
- shrinks on cooling to easily release from molds
2 Types of Suppository Bases
- oleaginous (fatty) bases — cocoa butter, fattibase
- water soluble/miscible bases — polyethylene glycol (PEG)
Oily bases _____ while water miscible bases _____
oil bases MELT while water miscible bases DISSOLVE
If the drug is OIL SOLUBLE in an OILY BASE —> drug abs will be ___
SLOW
If the drug is WATER SOLUBLE in an OILY BASE —> drug abs will be ___
RAPID
If the drug is OIL SOLUBLE in an WATER MISCIBLE BASE —> drug abs will be ___
MODERATE
If the drug is WATER SOLUBLE in an WATER MISCIBLE BASE —> drug abs will be ___
MODERATE
3 Methods of Suppository Preparation:
- hand rolling - rarely used needs lot of experience
- compression molding - not often used
- fusion molding - base is melted and drug is dissolved in melted base –> poured into mold –> remove when cooled
Mold calibration
average mass of one pure base suppository cast in the mold
mold specific, base specific, —- NOT drug specific
density factor
ration of a unit mass of drug powder to the amount of suppository base displaced by powder
NOT mold specific — base and drug specific
what is the density factor used for
used to determine how much base will be displaced by drug
when is the density factor needed
a. when drug has quantity dose and is being used for systemic effect
b. quantity of drug is a relatively significant portion of dosage form
c. density differences exist between base and drug
when using a mold lubricating/release agent….
agent should NOT be miscible with suppository base
- green soap for cocoa butter and Fattibase
- mineral oil or PEG/glycerin
Avoid using _____ in supository compounding because ____
avoid using WATER
b/c:
- supports bacterial growth
- incr drug degredation
- accelerates fatty oxidation
- contributes to brittleness
BUD for suppository
180 days (6 months)
Patient counseling points for suppositories
- instruct on proper admin technique
- remove foil/plastic wrap
- store properly
