Powders Flashcards
define compounding
preparation of a drug by a pharmacist to meet unique individual needs
3 Clinical scenarios that require compounding
- drug/dosage form is no commercially available
- dose unavailable
- formulation not appropriate (allergy, etc)
Compounding vs. Manufacturing
Compounding - preparing a drug in accordance to a prescription/med order — creates PREPARATIONS — includes batching
Manufacturing - preparing drugs for long-term inventory/sales — creates PRODUCTS — requires a special license due to different laws
batching
compounding ahead of time in anticipation of outstanding refills (only batch if you have an rx and it has refills)
3 Provisions for SAFE, ACCURATE & LEGAL compounding
- practice techniques for calculating/weighing
- master compounding formula sheets, records, standard operating procedures
- adherence to rules/regulations
Advantages of POWDER dosage form (6)
- tailored doses to pt
- easy to admin for pts who can’t swallow
- bad tastes are less noticable
- rapid onset (no disintigration required)
- external/internal use
- can be made into other dosage forms (capsules, topicals, etc)
1 kg = ___ lbs
1 kg = 2.2 lbs
1 inch = ___ cm
1 inch = 2.54 cm
BSA formula
BSA = sqrt (length cm * wt kg / 3600)
prepare #1 extra dose for _______ preparations
powder
how many extra doses should you prepare for POWDER preparations
1 extra dose
use a bulking agent if…
the volume is too small to be properly weighed on a balance
communition
reducing the particle size of a powder
reducing the particle size of a powder
communition
trituration
grinding into a finer powder
process of grinding into a finer powder (decr particle size)
trituration
levigation
reduces particle size by triturating in a mortal with a small amount of liquid (in which the solid is NOT soluble)
reduces particle size by triturating in a mortal with a small amount of liquid (in which the solid is NOT soluble)
levigation
creating a homogenous mixture
blending
smaller volume powder is triturated with an equal volume of other powder —> that mix is mixed with an equal volume of larger volume of powder –> repeat until complete
geometric dilution
BUD for powders
6 months OR not later than any exp date of a material you are using
Powder paper calculation steps:
- convert length/weight to cm/kg
- calc BSA (BSA = sqrt[ length.cm * weight.kg / 3600)
- multiply this to find mg per day (TDD)
- divide by # of doses per day (Q8H, BID, etc)
what is the minimum weighable quantity for lab scale?
100 mg
summarize a compounding procedure for a powder paper
review this
