Powders

Question 1

define compounding

Answer 1

preparation of a drug by a pharmacist to meet unique individual needs

Question 2

3 Clinical scenarios that require compounding

Answer 2

1. drug/dosage form is no commercially available
2. dose unavailable
3. formulation not appropriate (allergy, etc)

Question 3

Compounding vs. Manufacturing

Answer 3

Compounding - preparing a drug in accordance to a prescription/med order — creates PREPARATIONS — includes batching

Manufacturing - preparing drugs for long-term inventory/sales — creates PRODUCTS — requires a special license due to different laws

Question 4

batching

Answer 4

compounding ahead of time in anticipation of outstanding refills (only batch if you have an rx and it has refills)

Question 5

3 Provisions for SAFE, ACCURATE & LEGAL compounding

Answer 5

1. practice techniques for calculating/weighing
2. master compounding formula sheets, records, standard operating procedures
3. adherence to rules/regulations

Question 6

Advantages of POWDER dosage form (6)

Answer 6

• tailored doses to pt
• easy to admin for pts who can’t swallow
• bad tastes are less noticable
• rapid onset (no disintigration required)
• external/internal use
• can be made into other dosage forms (capsules, topicals, etc)

Question 7

1 kg = ___ lbs

Answer 7

1 kg = 2.2 lbs

Question 8

1 inch = ___ cm

Answer 8

1 inch = 2.54 cm

Question 9

BSA formula

Answer 9

BSA = sqrt (length cm * wt kg / 3600)

Question 10

prepare #1 extra dose for _______ preparations

Answer 10

powder

Question 11

how many extra doses should you prepare for POWDER preparations

Answer 11

1 extra dose

Question 12

use a bulking agent if…

Answer 12

the volume is too small to be properly weighed on a balance

Question 13

communition

Answer 13

reducing the particle size of a powder

Question 14

reducing the particle size of a powder

Answer 14

communition

Question 15

trituration

Answer 15

grinding into a finer powder

Question 16

process of grinding into a finer powder (decr particle size)

Answer 16

trituration

Question 17

levigation

Answer 17

reduces particle size by triturating in a mortal with a small amount of liquid (in which the solid is NOT soluble)

Question 18

reduces particle size by triturating in a mortal with a small amount of liquid (in which the solid is NOT soluble)

Answer 18

levigation

Question 19

creating a homogenous mixture

Answer 19

blending

Question 20

smaller volume powder is triturated with an equal volume of other powder —> that mix is mixed with an equal volume of larger volume of powder –> repeat until complete

Answer 20

geometric dilution

Question 21

BUD for powders

Answer 21

6 months OR not later than any exp date of a material you are using

Question 22

Powder paper calculation steps:

Answer 22

1. convert length/weight to cm/kg
2. calc BSA (BSA = sqrt[ length.cm * weight.kg / 3600)
3. multiply this to find mg per day (TDD)
4. divide by # of doses per day (Q8H, BID, etc)

Question 23

what is the minimum weighable quantity for lab scale?

Answer 23

100 mg

Question 24

summarize a compounding procedure for a powder paper

Answer 24

review this