Supportive Care Antimetabolites Flashcards
Which drug class do the following fall in?
cyclophospamide/ifosfamide
cisplatin/carboplatin/oxaliplatin
a. alkylating agents
b. antimetabolites
c. antimicrotubules
a. alkylating agents
What drug class do the following fall in?
vincristine/vinblastine/vinorelbine
a. antimicrotubules
b. alkylating agents
c. antimetabolites
a. antimicrotubules
What drug class do the following fall in?
methotrexate
mercaptopurine
fluorouracil
cytarabine
a. antimicrotubules
b. alkylating agents
c. antimetabolites
c. antimetabolites
What metabolite of cyclophosphamide causes toxicity?
acrolein
Mesna is given for supportive care with what agents?
cyclophosphamide
ifosfamide
helps with hemorrhagic cystitis
Methylene blue is given with what agent as supportive care?
ifosfamide
What is dose limiting toxicity of cyclophosphamide?
myelosuppression
What is dose limiting toxicity of ifosfamide?
hemorrhagic cystitis
What is most emetogenic alkylating agent?
cisplatin
Which platinum drug has minimal nephrotoxicity or ototoxicity?
oxaliplatin
what agent is given to help with ototoxicity/nephrotoxicity of platinums?
amifostine
What drug is 100% fatal if given intrathecally?
vincristine
Use __ compress with vincristine
a. warm
b. cold
a. warm
Avoid cold temps/drinks, etc with what platinum drug?
oxaliplatin
Vincristine does not cause n/v
a. true
b. false
a. true
What is main AE of paclitaxel?
peripheral neuroapthies
Premedicate with what 3 things to avoid hypersensitivity rxns with paclitaxel?
dexamethasone
diphenhydramine
famotidine
The main toxicities of the antifolaxe pemetrexed are bone marrow suppression and __
rash
Main toxicity of methotrexate?
nephrotoxicity
Glucarpidase is a supportive Tx for what drug?
methotrexate
cleaves anything that looks like folate into inactive form
Main toxicity of the antimetabolite mercaptopurine?
hepatotoxicity
__ are dose limiting toxicities with continuous infusion 5FU
a. leukopenia, thrombocytopenia, anemia
b. Mucositis, photosensitivity
b. Mucositis, photosensitivity
__ are dose limiting toxicities with bolus administration 5FU
a. leukopenia, thrombocytopenis, anemia
b. mucositis, photosensitivity
a. leukopenia, thrombocytopenis, anemia
5FU is contraindicated in pts with __ or MI within the past __ months
active infection, 6
Leucovorin is a rescue agent for 5FU
a. true
b. false
b. false
not a rescue agent but a primer of cells for greater cytotoxicity
leucovorin primes cells to get into replication phase and helps 5FU kill better
Which drug has toxicity of chemical conjunctivitis and fever?
cytarabine
antimetabolite
What is supportive care drug for cytarabine?
dexamethasone eye drops q4-6hrs continue 48hrs post completion of last dose
If homozygous for UGT1A1, reduce irinotecan dose by __ %
75
Use __ compress with anthracyclines
a. warm
b. cold
b. cold
anthracycline is closer to āCā so use cold compress
__ can be used as antidote for drug extravasations with anthracyclines (doxorubicin, daunorubicin, idarubicin, mitoxantrone)
dexrazoxane
Epipodophyllotoxins are forced into solution with what?
polysorbate 80
causes infusion rxns
Main toxicity of bleomycin?
pulmonary fibrosis
antitumor antibiotic
no scuba diving!!
Which two drugs do NOT cause n/v?
vincristine
asparaginase
