Mucositis and vomiting Flashcards
What is only FDA approved drug for prevention of chemo-induced mucositis?
palifermine (Kepivance)
limited experience with safety other than autologous HSCTs
3 neurotransmitters in the GI tract, vomiting center, and chemoreceptor trigger zone?
serotonin
dopamine
neurokinin
Heavy alcohol use vomit more than those without
a. true
b. false
b. false
vomit less
strange huh
delayed emesis occurs __ hours after chemo
24
palonsetron half life?
40 hours
which serotonin antagonist should not be administered at less than 1 week intervals
granisetron
which serotonin antagonist is CI for CINV?
doalsetron
ondansetron single IV dose is > _ mg
16
What is name of combo netupitant/fosnetupitant drug?
Akynzeo
Use caution when prescribing olanzapine with what drug?
metoclopramide
cannabinoids are not first line for anti-emesis
a. true
b. false
a. true
b/c of AEs
What do phenothiazines block?
dopamine
prochlorperazine
promethazine
3 drugs/classes given for low emetic risk?
metoclopramide
prochlorperazine
5HT3A
PRN meds recommended for low emetic risk unless active n/v
a. true
b. false
a. true
What is most appropriate agent for anticipatory n/v?
a. dronabinoo
b. metoclopramide
c. lorazepam
d. ondansetron
d. lorazepam
