Support Tissues Flashcards

1
Q

Connective tissues experience which types of forces?

A

compression tension shear

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2
Q

Where is loose connective tissue found?

A

between many organs

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3
Q

Functions of loose connective tissue?

A

space filling binding energy storage cushioning movement immune function

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4
Q

Main fibre types in loose connective tissue?

A

collagen and elastic fibres

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5
Q

Role of collagen in connective tissue?

A

provides stretch resistance

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6
Q

Role of elastic fibres in connective tissue?

A

provides recoil

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7
Q

What does ground substance contain in loose CT?

A

polysaccharides like hyaluronan which hold water

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8
Q

Types of loose connective tissue?

A

adipose areolar reticular

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9
Q

Function of adipose tissue?

A

energy storage insulation protection heat generation

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10
Q

Function of areolar tissue?

A

structural support and space filling

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11
Q

Function of reticular tissue?

A

forms a mesh-like network to support and allow cell movement

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12
Q

Most abundant resident cell in loose CT?

A

fibroblast

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13
Q

Function of fibroblast?

A

secretes proteins and polysaccharides to form extracellular matrix

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14
Q

Function of adipocytes?

A

store lipids as large droplets

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15
Q

Types of adipocytes?

A

white and brown

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16
Q

Function of mast cells?

A

release histamine and heparin for inflammatory response

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17
Q

Function of endothelial cells?

A

form a tight barrier lining of vessels

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18
Q

Function of pericytes?

A

maintain capillary stability and integrity

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19
Q

What are immigrant cells in loose CT?

A

monocytes macrophages lymphocytes

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20
Q

Role of monocytes?

A

migrate to tissue and become macrophages or dendritic cells

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21
Q

Role of macrophages?

A

phagocytosis and antigen presentation

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22
Q

Role of lymphocytes?

A

immune surveillance T cells attack pathogens B cells form plasma cells

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23
Q

What distinguishes dense CT from loose CT?

A

more collagen fibres greater tensile strength

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24
Q

Two types of dense connective tissue?

A

regular and irregular

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25
Arrangement of fibres in regular dense CT?
parallel
26
Function of regular dense CT?
tensile strength in one direction
27
Arrangement of fibres in irregular dense CT?
random
28
Function of irregular dense CT?
strength in multiple directions
29
Functions of cartilage?
connects bones cushions joints shock absorption protects bone ends
30
Key proteoglycan in cartilage?
chondroitin sulphate
31
Three types of cartilage?
hyaline elastic fibrocartilage
32
Most common cartilage type?
hyaline cartilage
33
Structure of hyaline cartilage?
short dispersed collagen lots of proteoglycans
34
Appearance of hyaline cartilage?
glassy
35
Function of hyaline cartilage?
smooth strong flexible resists compression
36
Locations of hyaline cartilage?
joint surfaces foetal skeleton tracheal rings
37
Main ECM components in hyaline cartilage?
collagen fibres and proteoglycans
38
Role of proteoglycans in cartilage?
absorb water create pressure to resist compression
39
Arrangement of fibres at articular surface?
parallel to surface
40
Arrangement of fibres deeper in cartilage?
perpendicular to surface
41
What distinguishes elastic cartilage?
contains elastic fibres
42
Function of elastic cartilage?
rigidity with flexibility
43
Locations of elastic cartilage?
ear epiglottis
44
What distinguishes fibrocartilage?
dense collagen fibres some proteoglycan visible fibrous structure
45
Function of fibrocartilage?
high tensile strength and resistance to compression
46
Locations of fibrocartilage?
intervertebral discs knee meniscus TMJ
47
What is bone mainly composed of?
calcified collagen ECM
48
What gives bone high compression resistance?
calcification
49
What gives bone high tensile resistance?
collagen
50
Is bone vascular and innervated?
yes
51
Types of bone structure?
spongy and compact
52
What are osteogenic cells?
bone stem cells that divide and become osteoblasts
53
Where are osteogenic cells found?
deep periosteum and bone marrow
54
Function of osteoblasts?
form new bone secrete matrix and calcium salts
55
What happens to osteoblasts after bone matrix forms?
they become osteocytes
56
Function of osteocytes?
maintain mineral concentration of bone matrix
57
Function of osteoclasts?
resorb bone multinucleated derived from WBCs
58
What is ossification?
formation of bone
59
Types of ossification?
intramembranous and endochondral
60
Intramembranous ossification forms which bones?
flat bones of skull and face
61
Does intramembranous ossification use cartilage?
no
62
Steps in intramembranous ossification?
mesenchymal cells osteoblasts osteocytes vascularisation spongy bone
63
Growth in intramembranous ossification?
appositional
64
Endochondral ossification forms which bones?
long bones
65
Does endochondral ossification use cartilage?
yes hyaline cartilage model
66
Steps in endochondral ossification?
mesenchyme chondroblasts cartilage model calcifies blood vessels invade osteoblasts form bone
67
Primary ossification centre?
diaphysis
68
Secondary ossification centre?
epiphysis
69
What is articular cartilage?
cartilage that remains at bone ends after ossification
70
What is the epiphyseal plate?
growth plate between bone and cartilage allowing length growth
71
Zones in epiphyseal cartilage?
resting proliferative hypertrophic calcification ossification
72
What happens in the resting zone?
receives growth signals
73
What happens in proliferative zone?
chondrocytes divide in columns
74
What happens in hypertrophic zone?
chondrocytes enlarge and secrete calcified matrix
75
What happens in calcification zone?
cartilage calcifies and nutrient supply is cut off
76
What happens in ossification zone?
chondrocytes die osteoblasts invade and replace with bone