Supplements in Metabolic Disease

Question 1

CAM definition

Answer 1

• Complementary Medicine: Medicine is used together with conventional western medicine
• Alternative Medicine: Medicine is used in place of conventional western medicine
• Complementary and Alternative Medicine (CAM) = Using therapies that are proven safe and effective and adopting them into conventional health care

Question 2

Purpose of Dietary Supplement and Health Education Acty (DSHEA)

Answer 2

• Evaluates vitamins, herbals, AAs, botanicals
• Regulates them like food
• Makes it so they can’t be on the same shelves as OTC medications

Question 3

Signs that distinguish higher quality supplements

Answer 3

• Product has a supplement seal of approval

Question 4

Commonly used supplements to tx dyslipidemia

Answer 4

• effective
  
  • fish oil
• likely effective
  
  • plant sterols
  • plant stanols

Question 5

Common supplements used for weight loss/obesity

Answer 5

• ephedra
  
  • risks outweigh benefits
• bitter orange
  
  • no evidence that safer than ephedra
• calcium
• alli
  
  • FDA approved for long term weight loss

Question 6

Common supplements used to tx Diabetes

Answer 6

• Chromium
• Vanadium

Question 7

Common supplements used to tx HTN

Answer 7

• garlic
• coenzymes q-10

Question 8

OTC products that have safetu concerns when used in metabolic disease

Answer 8

• Ephedra
• bitter orange
• 5-HTP
• aristolochia

Question 9

Potential drug interactions with OTC products/supplements

Answer 9

• Flaxseed + Anticoagulants
• Red yeast rice + CYP3A4, cyclosporine, gemfibrozil
• Orlistat + Anticoagulants, amiodarone, levothyroxine, vitamins
• Chromium + Insulin, levothyroxine, NSAIDs and corticosteroids
• Α linoleic acid + antidiabetes agents and chemotherapy

Question 10

Supplements/OTCs that have solid evidence for tx of metabolic disease

Answer 10

• fish oil ==> lower TGs

Question 11

Some/limited evidence for OTCs tx of dyslipidemia

Answer 11

• likely effective
  
  • barley
  • beta-glucans
  • blond psylium
  • niacin
  • oat bran
• possibly effective
  
  • flaxseed
  • guar gum
  • soy
• insufficient evidence
  
  • alpha linolenic acid

Question 12

Some/limited evidence for OTCs tx of obesity

Answer 12

• possibly effective
  
  • blond psylium
  • calcium
• insufficient evidence
  
  • barley
  • chromium
  • st. john’s wort

Question 13

Some/limited evidence for OTCs tx of diabetes

Answer 13

• possibly effective
  
  • blond psylium
  • guar gum
  • Mg
  • oat bran
  • soy
• insufficient evidence
  
  • cassia cinnamon
  • co-q10
  • stevia
  • vanadium

Question 14

Some/limited evidence for OTCs tx of HTN

Answer 14

• possibly effective
  
  • alpha linolenic acid
  • blond psylium
  • calcium
  • cocoa
  • coq10
  • fish oil
  • vitamin C
• insufficient evidence
  
  • black/green tea
  • DHA
  • hibiscus, pomegranit
  • Mg
  • soy