Supplements Flashcards
According to St. John Wort, supplements are used to benefit what?
mild to moderate depression
Mechanism of supplements?
inhibits metabolism and reuptake of serotonin, dopamine, and epinephrine
According to St. John Wort, are supplements more effective than placebo for mild to moderate depression?
NO
Limitations to supplements?
- short duration
- did not use DSM criteria
- variable doses used
- comparative doses of Rx antidepressants were typically subtherapeutic
- associated with allergic reactions and photosensitization; no evidence for efficacy
- drug interactions do exist - strong inducer of CYP and p-glycoprotein
Are herbs and supplements regulated by any governing body?
NO
Garlic supplements potentially inhibit what?
cholesterol synthesis
Garlic supplements effect what?
plasma protein and cell membrane remodeling
What other activity/ability is possible of garlic supplements?
- lipid-lowering ability
- anti-hypertensive effect
- lower LDL’s
- antiplatelet, antithrombotic, and fibrinolytic activity
Reasons for recommending garlic supplements?
- probably safe
- inexpensive
- few side effects
- must use high doses
Glucosamine: metabolized where? incorporated into what? distributed where?
metabolized in the liver, incorporated into plasma proteins, distributed in liver/kidneys/articular cartilage
Where is chondroitin distributed?
into various tissues, primarily cartilage
Exogenuos glucosamine distributes where and increases the synthesis of what?
distributed to joints (knees) and increases the synthesis of hyaluronic acid
Was there a benefit seen relative to placebo in short term treatment with glucosamine chondroitin sulfate?
NO
Is there a benefit for short term treatment in patients with moderate to severe OA?
YES
