Summary of Resistance Mechanisms Flashcards
Beta-lactams Examples
Penicillins
cephalosporins
carbapenems
monobactams
Beta-lactams Resistance Mechanism
Hydrolysis (β-lactamase);
altered target site
efflux
Aminoglycosides Examples
Gentamicin, tobramycin,
amikacin
Aminoglycosides Resistance Mechanism
Aminoglycoside-modifying enzymes
altered target site
efflux
Glycopeptides Example
Vancomycin
Glycopeptides Resistance Mechanism
Altered cell wall precursors
Lipopeptides Examples
Daptomycin
Lipopeptide Resistance Mechanism
Altered target site
thickening peptidoglycan structure
Tetracyclines Examples
Doxycycline, minocycline
Tetracyclines Resistance Mechanism
Altered target site
efflux
Glycylcycline Examples
Tigecycline
Glycylcycline Resistance Mechanism
Altered target site
efflux
Macrolides Examples
Erythromycin
azithromycin
clarithromycin
Macrolides Resistance Mechanism
Altered target site
efflux
Lincosamides Examples
Clindamycin