Summary of Resistance Mechanisms Flashcards

1
Q

Beta-lactams Examples

A

Penicillins

cephalosporins

carbapenems

monobactams

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2
Q

Beta-lactams Resistance Mechanism

A

Hydrolysis (β-lactamase);

altered target site

efflux

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3
Q

Aminoglycosides Examples

A

Gentamicin, tobramycin,

amikacin

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4
Q

Aminoglycosides Resistance Mechanism

A

Aminoglycoside-modifying enzymes

altered target site

efflux

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5
Q

Glycopeptides Example

A

Vancomycin

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6
Q

Glycopeptides Resistance Mechanism

A

Altered cell wall precursors

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7
Q

Lipopeptides Examples

A

Daptomycin

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8
Q

Lipopeptide Resistance Mechanism

A

Altered target site

thickening peptidoglycan structure

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9
Q

Tetracyclines Examples

A

Doxycycline, minocycline

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10
Q

Tetracyclines Resistance Mechanism

A

Altered target site

efflux

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11
Q

Glycylcycline Examples

A

Tigecycline

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12
Q

Glycylcycline Resistance Mechanism

A

Altered target site

efflux

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13
Q

Macrolides Examples

A

Erythromycin

azithromycin

clarithromycin

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14
Q

Macrolides Resistance Mechanism

A

Altered target site

efflux

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15
Q

Lincosamides Examples

A

Clindamycin

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16
Q

Lincosamides Resistance Mechanism

A

Altered target site

efflux

17
Q

Streptogramins Examples

A

Quinupristin/dalfopristin

18
Q

Streptogramins Resistance Mechanism

A

Altered target site

efflux

acetylation

19
Q

Oxazolidinones Examples

A

Linezolid

tedizolid

20
Q

Oxazolidinones Resistance Mechanism

A

Altered target site

efflux

21
Q

Fluoroquinolones Examples

A

Ciprofloxacin

levofloxacin

moxifloxacin

22
Q

Fluoroquinolones Resistance Mechanism

A

Altered target site

efflux

23
Q

Pyrimidines Examples

A

Trimethoprim

24
Q

Pyrimidines Resistance Mechanism

A

Altered target site

efflux

25
Q

Sulfonamides Examples

A

Sulfamethoxazole

26
Q

Sulfonamides Resistance Mechanism

A

Altered target site

efflux

27
Q

Rifamycins Examples

A

Rifampin

28
Q

Rifamycins Resistance Mechanism

A

ADP-ribosylation

altered target site

efflux

29
Q

Cationic peptides Examples

A

Colistin

polymyxin B

30
Q

Cationic peptides Resistance Mechanism

A

Altered target site

efflux