Summary of biochemical changes in metabolic bone disorders

Question 1

1) What happens to calcium in primary hyperparathyroidism
2) What happens to calcium in renal osteodystrophy
3) What happens to calcium in osteomalacia/Rickets
4) What happens to calcium in Paget’s disease
5) What happens to calcium in osteoporosis

Answer 1

1) Raised
2) Normal or low
3) Normal or low
4) Normal
5) Normal

Question 2

1) What happens to phosphate in primary hyperparathyroidism
2) What happens to phosphate in renal osteodystrophy
3) What happens to phosphate in osteomalacia/Rickets
4) What happens to phosphate in Paget’s disease
5) What happens to phosphate in osteoporosis

Answer 2

1) Low
2) Raised
3) Low
4) Normal
5) Normal

Question 3

1) What happens to ALP in primary hyperparathyroidism
2) What happens to ALP in renal osteodystrophy
3) What happens to ALP in osteomalacia/Rickets
4) What happens to ALP in Paget’s disease
5) What happens to ALP in osteoporosis

Answer 3

1) Normal/raised
2) Raised
3) Raised
4) Raised
5) Normal

Question 4

1) What happens to PTH in primary hyperparathyroidism
2) What happens to PTH in renal osteodystrophy
3) What happens to PTH in osteomalacia/Rickets
4) What happens to PTH in Paget’s disease
5) What happens to PTH in osteoporosis

Answer 4

1) Raised
2) Raised
3) Normal/raised
4) Normal
5) Normal