Summary of ABs

Question 1

The inhibitors of Nucleic Acid Synthesis

Answer 1

Sulfonamides, Trimethoprim, Rifampin

Question 2

what are the bacteriostatic ABs that are inhibitors of nucleic acid synthesis

Answer 2

Sulfonamides and Trimethoprim

Question 3

What is the bactericidal AB that are inhibitors of nucleic acid synthesis

Answer 3

Rifampin

Question 4

What are the DNA damaging ABs

Answer 4

quinolones, nitrofurantoin, metronidazole, methenamine

Question 5

What DNA damaging AB is bacteriostatic

Answer 5

Nitrofurantoin

Question 6

What DNA damaging ABs are bactericidal

Answer 6

Quinolones, Metronidazole, Methenamine

Question 7

What are the ABs that are inhibitors of Cell membrane synthesis

Answer 7

B lactams, carbapenems, monobactams, vancomycin, bacitracin, cephalosporins

Question 8

What are the bactericidal ABs that are inhibitors of cell membrane synthesis

Answer 8

ALL Cell membrane synthesis inhibitors are CIDAL!

Question 9

What ABs are inhibitors of cell membrane function

Answer 9

Polymyxins, Daptomycin

Question 10

Polymyxin is cidal or static

Answer 10

Polymyxins are CIDAL!

Question 11

Daptomycins are cidal or static

Answer 11

Daptomycins are CIDAL!

Question 12

What ABs are inhibitors of protein synthesis

Answer 12

Linezolid, Tetracylines, Tigecylcine, Aminoglycosides, chloramphenicol, macrolides, clindamycin, the combo of Quinupristin/ dalfopristin

Question 13

What are the macrolides and what do they do?

Answer 13

Macrolides: erythromycin, azithromycin, clarithromycin

Question 14

What protein synthesis inhibitors are cidal?

Answer 14

Aminoglycosides and the combo of quinupristin/ dalfopristin

Question 15

MoA of sulfonamides

Answer 15

Inhibit nucleic acid synthesis by inhibiting dihydropteroic acid synthesis in folic acid pathway

Question 16

MoA of Trimethoprim

Answer 16

Inhibit nucleic acid synthesis by inhibiting dihydropteroic acid synthesis in folic acid pathway

Question 17

MoA of Rifampin

Answer 17

Inhibit RNA synthesis

Question 18

MoA of quinolones

Answer 18

Quinolones: Induce DNA damage by inhibition of DNA gyrase A and topoisomerase

Question 19

MoA of nitrofurantoin

Answer 19

Nitrofurantoin produces ROS causing DNA damage

Question 20

What drugs inhibit protein synthesis by binding to the 50s ribosome

Answer 20

Aminoglycosides, chloramphenicol, macrolides, clindamycin, Linezolid, combo of quinupristin/ dalfopristin

Question 21

MoA of metronidazole

Answer 21

Metronidazole- nitro reduction activates drug which binds to and causes DNA damage

Question 22

MoA of methenamine

Answer 22

Methenamine: hydrolyzes to formaldehyde which damages DNA

Question 23

What binds to the 30s ribosome to inhibit protein synthesis

Answer 23

tetracylcines and tegicylcines

Question 24

MoA of the B lactams?

what are the B lactams?

Answer 24

MoA of B Lactams: inhibit cell membrane synthesis by preventing transpeptidation cross linking
B lactams: penicillins, carbapenems, monobactams, cephalosporins

Question 25

MoA of Daptomycin

Answer 25

Daptomycin is cidal by disrupting membrane functioning binding lipopeptide to the membrane

Question 26

MoA of Vancomycin. Vancomycin acts against what?

Answer 26

Vancomycin GRAM + ONLY!

Vancomycin binds to D ala D ala preventing polymerization of linear peptidoglycan

Question 27

MoA of Polymyxins

Answer 27

Polymyxins act as cationic detergent disrupting cell membrane

Question 28

MoA of Bacitracin

Answer 28

Bacitracin is tidal and binds to lipid carrier of peptoglycans preventing delivery for cell wall synthesis

Question 29

The 8 bacteriostatic ABs

Answer 29

Sulfonamides, Trimethoprim, Tetracyclines, Linezolid, nitrofurantoin, chloramphenicol, macrolides, clindamycin

Question 30

What are the bactericidal ABs

Answer 30

Rifampin, B lactams, polymyxins, daptomycin, aminoglycosides, Quinolones, metronidazole, methenamine, Vancomycin, bacitracin
Quinupristin/ dalfopristin