Antifungals that target cell wall

Question 1

what drug class targets the fungal cell wall? name the 3 drugs in this class

Answer 1

echinocandins target cell wall

echinocandins= caspofungin, micafungin, and anidufungin

Question 2

what is the MoA of echinocandins?

Answer 2

MoA of echinocandins= osmotic lysis due to loss of cell wall integrity thru inhibition of B 1,3 glucan synthase

Question 3

How do Echinocandins affects the cell wall of fungi?

Answer 3

thru inhibition of B glucan synthase

Question 4

what are echinocandins?

Answer 4

semisynthetic lipopeptides designed to tx systemic fungal infections due to resistance to Amphotericin B, Triazoles, and 5FC

Question 5

Echinocandins 
absorption:
metabolism/ excretion:
Toxicity:
Drug to drug interactions:

Answer 5

Echinocandins
Absorption: IV ONLY!! poor CNS penetration, highly protein bound
Metabolism: liver > cleavage of peptide bonds, slow excretion in bile and urine
Toxicity well tolerated, some fevers and allergies
drug to drug: LOW due to weak P450 interactions