Antifungals that target Protein synthesis inhibition

Question 1

what drug targets proteins synthesis inhibition?

Answer 1

tavaborole

Question 2

How does tavaborole inhibit protein synthesis?

Answer 2

inhibits Leucyl -tRNA synthetase

Question 3

MoA of tavaborole?

Answer 3

inhibits ability of Leucyl-tRNA to be attached to leucine, forming a covalent adduct with the tRNA for leucine in complex with Leucyl-tRNA synthetase enzyme. Thus inhibiting protein synthesis by not making amino-acyl tRNA for leucine available

Question 4

Tavaborole
Specificity:
Clinical Activity:
Toxicity:

Answer 4

Tavaborole:
Specificity: Mammalian enzyme different structure at critical AA recognition site
Clinical Activity: Topical for onychomycosis of nails with ciclopirox. Good nail penetration
Toxicity: none