Summary - MSK Flashcards
Describe osteoarthritis
Long term condition of synovial joints where there is damage causing repair leading to structural changes
Loss of cartilage, bone and mild synovitis
Knees, hips, small joints of hand most affected
What are the signs and symptoms of OA?
Pain, stiffness, and loss of function
Possible bony swelling, joint deformity, painful/ restricted movement, crepitus, and joint instability
Heberden’s and Bouchard’s (proximal) nodes
What is the clinical history of OA?
Activity related joint pain plus has morning related joint stiffness or morning stiffness lasting more than 30 mins
What is the management and treatment for OA?
Exercise and weight loss
Thermotherapy, electrotherapy, and aids
Paracetamol and NSAIDs
Topical treatments - NSAIDs and capsaicin
Intra-articular injections
Surgical
Describe septic arthritis
Acute synovitis with purulent joint effusion
Articular cartilage is attacked by bacterial toxin and cellular enzymes
Common organism - staph aureus and strep. pyogenes.
What are some causes of Septic arthritis?
Infected joint replacement, age and immunosuppression
What are the symptoms and signs of septic arthritis?
Presents with hot, swollen, acutely painful joint with restricted movement
Fever, increased tenderness, increased pulse, and not erythema
What is the gold standard investigation for septic arthritis?
Joint aspiration
What is the treatment for septic arthritis?
General supportive measures
Antibiotics for 3-4 weeks
Surgical drainage and lavage in emergency
Describe osteomyelitis
Inflammatory condition of bone caused by infecting organism - commonly staph. aureus
Mainly in long bones and secondary OM is more common in adults
What are the symptoms of OM in infants and children?
Infants - failure to thrive, ill, irritable, swelling, and decreased ROM
Child - severe pain, fever, tachycardia, malaise and toxaemia
What are the signs and symptoms for OM in adults?
Backache as commonly thoracolumbar spine, history of UTI, and risk factors present
What is the treatment for osteomyelitis?
General care, analgesia and splints
Antibiotics - IV/ oral switch for 4-6 weeks
Surgery if aspiration of pus, abscess drainage, debridement of infected tissue and refractory to non-surgical treatment
Describe rheumatoid arthritis
Chronic autoimmune systemic inflammatory condition which is characterised by symmetrical polyarthritis
Commonly small joints of hand, wrist and feet
What is the symptoms and signs of RA?
Pain, morning stiffness for more than 30 mins, immobility, poor function and systemic symptoms
Swelling, tenderness, warmth, redness and limited ROM
Swan neck deformity and synovitis
What are the investigations for RA?
Bloods - FBC, Kidney function, LFTs, CRP, ESR, RF and anti-CCP antibodies
X-ray and US
DAS (disease severity score)
What is the management and treatment for RA?
NSAIDs and glucocorticoids - prednisolone/ hydrocortisone and dexamethasone
DMARDs - methotrexate, leflunomide and sulfasalazine
Biologics
Describe fibromyalgia
Centralised pain disorder characterised by severe pain and other features
Widespread pain, fatigue and difficulty concentrating
More women than men affected
What are the signs and symptoms of fibromyalgia?
Widespread pain in multiple regions of body for more than 3 months
Intrusive fatigue - emotional and physical
Increased sensitivity to light, sound and temp.
What is the management and treatment for fibromyalgia?
Pain related anxiety/ depression - CBT and SSRIs
Sleep disturbance - low dose amitriptyline and pregabalin
Severe pain - amitriptyline, gabapentin, pregabalin, duloxetine and tramadol
Physio
Describe hypermobility spectrum disorder (HSD)/ hypermobile Ehlers-Danlos syndrome (hEDS)
Connective tissue disorder which causes injury, pain, joint hypermobility and instability
Spectrum of hypermobility
Strongly genetically determined
Beighton diagnostic criteria
What are the signs and symptoms of HSD or hEDS?
Joint pain, myalgia, joint effusions, and soft tissue problems - bursitis, epicondylitis, and tendinopathies
Linked to CV and GI symptoms
Soft skin, easy bruising, papery scars, peizogenic papules and striae
What is the management for HDS or hEDS?
Appropriate physical therapy - strengthening and stretching
Core stability
Correct foot deformity and OT input
Describe gout
Type of arthritis caused by monosodium urate crystals forming inside and around joints
Sudden flares of heat, pain and swelling
Most commonly distal joints of toes
What is the most important risk factor for gout?
Hyperuricaemia
What are the symptoms of gout?
Rapid onset of pain with redness and swelling in one or more joints
Tophi - accumulation of uric acid
What is the investigation for gout?
Aspiration is gold standard
Also serum urate level measured
What is the management and treatment for gout?
Acute flares - NSAID,s colchicine and steroids
Long term - urate lowering therapy
First line is allopurinol and UTL is measured
2nd line is febuxostat
Lifestyle - weight, hydration, diet and limit alcohol
Describe pseudogout
Condition caused by deposition of calcium pyrophosphates on tissues and cartilage around joints
Most commonly affects the knee in elderly
What is the investigations for pseudogout?
X-rays - chondrocalcinosis
Aspiration to show crystals
What is the treatment for psuedogout?
NSAIDs, intra-articular steroids and no prophylatic treatments
Describe polymyalgia rheumatica
Chronic, systemic, rheumatoid disease characterised by pain and morning stiffness in neck, shoulder and pelvic gridle
Is associated with giant cell arthritis and high ESR anaemia