sulforaphane Flashcards
where is broccoli most abundant
broccoli sprouts
what is sulforaphane
a potent NQO1 inducer
what is sulforaphane isolated from
glucoraphanin via myosin
how does sulforaphane activate Nrf2
by reacting with cysteines (mainly C151) in Keap1
what effect does sulforaphane possess
cytoprotective and anti-inflammatory properties
increasing concentrations of sulforaphane protects against…
the toxicity of menadione (an oxidant)
what does activation of the Nrf2 pathway by sulforaphane protect against
streptozotocin-induced diabetic nephropathy
what does sulforaphane prevennt
diabetes-induced aortic damage
(shown using a diabetic mouse model - comparing WT to Nrf2 KO mice, KO have much more aortic DNA damage)
how does sulforaphane prevent diabetes-induced aortic damage
through the prevention of oxidative stress
what are the phenotypic corrections of diabetes-induced aortic damage projected by sulforaphane
thickening of the aorta is prevented,
much less DNA damage,
inflammation decreased
what does sulforaphane protect the brain against
hypoxic-ischemic injury
how does sulforaphane protect against hypoxic-ischemic injury
it reduced the number of damaged cells and protected neurons from apoptosis
what does sulforaphane decrease after spinal cord injury
inflammation and lesion volume
what happens to Nrf2 in cancer cells
it is upregulated
what inhibits growth of carcinogenesis in mice models
broccoli sprouts (a SFN source) and their isothiocyanates
what does sulforaphane need in order to provide protection
the presence of Nrf2
what is the largest and most easily accessible organ
the skin
damage by UV radiation is…
acceptable and objectively quantifiable
what is skin erythema
a biomarker of skin damage, including inflammation and vasodilation
what happens when sulforaphane levels become too high in humans
it can become toxic
how would you help trrat erythema developments
sulforaphane dose ~400nmol max
who are at a very high risk of skin cancer
transplant patients
