cell signalling Flashcards
name some types of signal molecules
- growth hormones
- hormones
- interleukins
- interferons
- chemokines
- extracellular matrix proteins
- toxins
- neurotransmitters
how do signal cells work
signal cell secretes ligands which binds to nearby cells with the appropriate receptor
what are extracellular matrix signals dependant on
cell-to-cell contact
what is angiogenesis
development of blood vessels
what cells do hedgehog receptors work in
stem cells
what are the different modes of signal transmission
- conformational-coupling (preformed complex)
- conformational-coupling (diffusion-dependant complex formation)
- posttranslational modification
- protein degradation
what is phosphorylation a primary mechanism of
signal relay
what do RTKs regulate and what do they promote
cell fate and cancer development
what did Rous discover
that a malignant tumour (sarcoma) in chickens was transmissable and also could be passed through a filter (and so was considered a virus)
what made Src transmissable
it contained tyrosine kinase activity
what is the human form of Src
cSrc
what do you need to target to avoid tumour growth
EGFR
how is EGFR activated
by a ligand binding to it
what does egfr stand for
epidermal growth factor receptor
what are RTK therapies in cancer aiming to do
slow down cancer, instead of curing it
