Sulfonmides

Question 1

Antimetabolites

Answer 1

1. Sulfonamides
2. Trimethoprim
3. Trimethoprim-Sulfamethoxazole

Question 2

FLUOROQUINOLONES

Answer 2

ategorized based on antimicrobial coverage:
1. Narrow Spectrum: 1st generation
2. Broad Spectrum: 2nd & 3rd generation as
well as 4th generation.

Question 3

sulfonamides are derivatives of the _______

Answer 3

para-aminobenzoic acid or sulfanilamide

Question 4

substitution in this group has variable effects on antibacterial activity

Answer 4

amide NH2 group (n1)

Question 5

T or F
Most are prepared as sodium salts and they are
given parenterally or per Orem.

Answer 5

T

Question 6

MOA of sulfonamides

Answer 6

Competitively inhibits dihydropteroate
synthase (responsible for incorporation of PABA
into dihydropteroic acid).

Question 7

Inhibits microbial dihydrofolate reductase.

Answer 7

Trimethoprim

Question 8

antimicrobial activity of sulfonamides

Answer 8

 Inhibits both Gram (+) & Gram (-) bacteria
“KNEESSSCP”
 Klebsiella
 Nocardia
 Enterobacter
 E. coli
 Staphylococci
 Salmonella
 Shigella
 Chlamydia trachomatis
 Protozoa

Question 9

Sulfonamides are not active against

Answer 9

 Stimulates growth of Rickettsia
 Poor activity vs Anaerobes
 Pseudomonas aeruginosa intrinsically resistant

Question 10

T or F
Sulfonamides may be given per orem,
parenterally or IV.

Answer 10

T