INTRODUCTION TO ANS Flashcards
inhibit tyrosine hydroxylase (rate limiting step)
metyrosine
inhibit vesicular transport of dopamine
reserpine
inhibits reuptake of NE
cocaine, TCAs, NERI
inhibits release of NE
guanethidine, bretylium, guanadrel
blocks the active uptake of choline
hemicholinium
blocks uptake of acetylcholine by different vesicular receptors
vesamicol
inhibit the release of acetylcholine or the attachment of acetylcholine to be released
Botulinum toxin
Primary transmitter at ANS ganglia, at somatic neuromuscular junction, At parasympathetic postganglionic nerve endings Excitatory transmitter to smooth muscle and secretory cells (ENS) Major neuron to neuron transmitter (ENS)
Acetylcholine
Primary transmitter at most
sympathetic post ganglionic nerve
endings
Norepinephrine
Transmitter or co-transmitter at
many ANS effector synapse
Adenosine
triphosphate
In Substance P in cardiovascular
sensory nerve fibers, secretomotor
ENS, a cardiac stimulant
Calcitonin gene
related peptide
Cotransmitter in some excitatory
neuromuscular ENS
Cholecystokinin
Modulatory transmitter in some
ganglia(ENS), a postganglionic
sympathetic transmitter in renal
blood cells
Dopamine
Secretomotor and interneurons (ENS) Inhibit acetylcholine release and inhibit peristalsis, stimulate secretion
Enkephalin
Secretomotor neurons, apetite
satiety mechanism
Galanin
Presynaptic effect on excitatory
ENS nerve terminals, relaxant
effect on the gut, not a major
transmitter
GABA
Co-transmitter at inhibitory
ENS neuromuscular junction,
important in sphincters
Nitric oxide
Potent excitatory transmitter to
gastrin cells. Mammalian bombesin
Gastrin releasing
peptide
In noradrenergic neuron, some secretomotor neurons (ENS) Inhibit secretion of water and electrolytes in the gut Long lasting vasoconstriction Cotransmitter(parasympathetic)
Neuropeptide Y
Important transmitter or
cotransmitter at excitatory neuron
to neuron
junctions (ENS)
Serotonin
Sensory neuron transmitter in the
ENS, excitatory cotransmitter with
ACH, vasodilator
Substance P
