INTRODUCTION TO ANS

Question 1

inhibit tyrosine hydroxylase (rate limiting step)

Answer 1

metyrosine

Question 2

inhibit vesicular transport of dopamine

Answer 2

reserpine

Question 3

inhibits reuptake of NE

Answer 3

cocaine, TCAs, NERI

Question 4

inhibits release of NE

Answer 4

guanethidine, bretylium, guanadrel

Question 5

blocks the active uptake of choline

Answer 5

hemicholinium

Question 6

blocks uptake of acetylcholine by different vesicular receptors

Answer 6

vesamicol

Question 7

inhibit the release of acetylcholine or the attachment of acetylcholine to be released

Answer 7

Botulinum toxin

Question 8

Primary transmitter at ANS ganglia, at somatic neuromuscular junction, At parasympathetic postganglionic
nerve endings
Excitatory transmitter to smooth
muscle and secretory cells (ENS)
Major neuron to neuron transmitter
(ENS)

Answer 8

Acetylcholine

Question 9

Primary transmitter at most
sympathetic post ganglionic nerve
endings

Answer 9

Norepinephrine

Question 10

Transmitter or co-transmitter at

many ANS effector synapse

Answer 10

Adenosine

triphosphate

Question 11

In Substance P in cardiovascular
sensory nerve fibers, secretomotor
ENS, a cardiac stimulant

Answer 11

Calcitonin gene

related peptide

Question 12

Cotransmitter in some excitatory

neuromuscular ENS

Answer 12

Cholecystokinin

Question 13

Modulatory transmitter in some
ganglia(ENS), a postganglionic
sympathetic transmitter in renal
blood cells

Answer 13

Dopamine

Question 14

Secretomotor and interneurons
(ENS)
Inhibit acetylcholine release and
inhibit peristalsis, stimulate
secretion

Answer 14

Enkephalin

Question 15

Secretomotor neurons, apetite

satiety mechanism

Answer 15

Galanin

Question 16

Presynaptic effect on excitatory
ENS nerve terminals, relaxant
effect on the gut, not a major
transmitter

Answer 16

GABA

Question 17

Co-transmitter at inhibitory
ENS neuromuscular junction,
important in sphincters

Answer 17

Nitric oxide

Question 18

Potent excitatory transmitter to

gastrin cells. Mammalian bombesin

Answer 18

Gastrin releasing

peptide

Question 19

In noradrenergic neuron, some
secretomotor neurons (ENS)
Inhibit secretion of water and
electrolytes in the gut
Long lasting vasoconstriction
Cotransmitter(parasympathetic)

Answer 19

Neuropeptide Y

Question 20

Important transmitter or
cotransmitter at excitatory neuron
to neuron
junctions (ENS)

Answer 20

Serotonin

Question 21

Sensory neuron transmitter in the
ENS, excitatory cotransmitter with
ACH, vasodilator

Answer 21

Substance P