Antifungal

Question 1

primary drugs used in systemic infections

Answer 1

amphotericin b, the azoles, and the echinocandins

Question 2

a sterol unique to fungal cell membranes

Answer 2

Ergosterol

Question 3

Squalene is converted to ________ —>______

Answer 3

lanosterol; ergosterol

Question 4

acts and binds to ergosterol-rich fungal cell membranes.

Answer 4

Amphotericin b

Question 5

blocks the conversion of lanosterol to ergosterol

Answer 5

Azoles

Question 6

block the conversion of squalene to lanosterol

Answer 6

Terbinafine, Naftifine and Amorolfine

Question 7

will act on microtubule system

Answer 7

Griseofulvin

Question 8

Flucytosine inhibits ______

Answer 8

DNA and RNA polymerases

Question 9

amphotericin b contains

Answer 9

polyene- containing many double bonds

macrolide- containing a large lactone ring of 12 or more atoms

Question 10

T or F

Oral amphotericin b is effective only on fungi within the lumen of the tract

Answer 10

T

Question 11

only __% of the blood level is reached in cerebrospinal fluid (amphotericin b)

Answer 11

2-3%

Question 12

Amphotericin b resistance

Answer 12

impaired ergosterol binding

Question 13

antifungal agent with the broadest spectrum of action

Answer 13

amphotericin b

Question 14

organisms causing endemic mycoses

Answer 14

Histoplasm capsulatum
Blastomyces dermatiditis
Coccidioides immitis

Question 15

Pathogenic molds

Answer 15

Aspergillus fumigatus and agents of mucormycosis

Question 16

Intrinsic amphotericin B resistance

Answer 16

Candida lusitaniae

Pseudallescheria boydii

Question 17

Used to access meninges

Remains an option in cases of fungal CNS infections that do not respond to other agents

Answer 17

intrathecal therapy (amphotericin b)

Question 18

tx option for candiduria

Answer 18

Bladder irrigation