Antifungal Flashcards
primary drugs used in systemic infections
amphotericin b, the azoles, and the echinocandins
a sterol unique to fungal cell membranes
Ergosterol
Squalene is converted to ________ —>______
lanosterol; ergosterol
acts and binds to ergosterol-rich fungal cell membranes.
Amphotericin b
blocks the conversion of lanosterol to ergosterol
Azoles
block the conversion of squalene to lanosterol
Terbinafine, Naftifine and Amorolfine
will act on microtubule system
Griseofulvin
Flucytosine inhibits ______
DNA and RNA polymerases
amphotericin b contains
polyene- containing many double bonds
macrolide- containing a large lactone ring of 12 or more atoms
T or F
Oral amphotericin b is effective only on fungi within the lumen of the tract
T
only __% of the blood level is reached in cerebrospinal fluid (amphotericin b)
2-3%
Amphotericin b resistance
impaired ergosterol binding
antifungal agent with the broadest spectrum of action
amphotericin b
organisms causing endemic mycoses
Histoplasm capsulatum
Blastomyces dermatiditis
Coccidioides immitis
Pathogenic molds
Aspergillus fumigatus and agents of mucormycosis
Intrinsic amphotericin B resistance
Candida lusitaniae
Pseudallescheria boydii
Used to access meninges
Remains an option in cases of fungal CNS infections that do not respond to other agents
intrathecal therapy (amphotericin b)
tx option for candiduria
Bladder irrigation
